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NU7441

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Cat.No：IN1430 Solarbio

CAS：503468-95-9

Molecular Formula：C₂₅H₁₉NO₃S

Molecular Weight：413.49

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	503468-95-9
Name	NU7441
Molecular Formula	C₂₅H₁₉NO₃S
Molecular Weight	413.49
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00038617
SMILES	O=C1C=C(N2CCOCC2)OC3=C1C=CC=C3C4=CC=CC5=C4SC6=C5C=CC=C6
Target Point	DNA-PK
Passage	DNA Damage/DNA Repair
Background	NU7441 is a highly potent and selective DNA-PK inhibitor.
Biological Activity	KU-57788 是一种有效的，选择性的 DNA-PK 抑制剂，IC50 值为 13 nM。[1-5]
Data Literature Source	[1]. Sunada S，et al. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair. Cancer Sci. 2016 Sep;107(9):1250-5 [2]. Yang C，et al. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells. Cell Physiol Biochem. 2016;38(5):1897-905 [3]. Hardcastle IR，et al. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46 [4]. Ember SW，et al. The acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS Chem Biol. 2014 Feb 25. [5]. Robert F，et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 Aug 27;7:93
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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