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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > IngenolCAS：30220-46-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 30220-46-3 |
| Name | Ingenol |
| Molecular Formula | C20H28O5 |
| Molecular Weight | 348.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD27980538 |
| SMILES | O[C@@]([C@@H](C(CO)=C[C@@]1([H])[C@H](C2(C)C)[C@H]2C3)O)([C@H]4O)[C@]([C@@H]3C)(C=C4C)C1=O |
| Target Point | PKC |
| Passage | TGF-beta/Smad;Epigenetics |
| Background | It is a diterpenoid related to phorbol with antitumor activity. |
| Biological Activity | Ingenol is a PKC activator， with a Ki of 30 μM， with antitumor activity.[1] |
| IC50 | PKC:30μM(Ki)[1] |
| In Vitro | Ingenol is a PKC activator，with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity(1，3 mM)，and causes morphological changes(1 mM)in primary mouse epidermal keratinocytes. Ingenol(125 μM，250 μM，500 μM，1 mM)also inhibits cell-cell communication[1]. |
| Data Literature Source | [1]. Hasler CM，et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52(1):202-8. |
| Unit | Bottle |
| Specification | 5mg 10mg |
是一种 PKC 激活剂，具有抗肿瘤活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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