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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > CK-636CAS：442632-72-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 442632-72-6 |
| Name | CK-636 |
| Molecular Formula | C16H16N2OS |
| Molecular Weight | 284.38 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD03036245 |
| SMILES | O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3 |
| Target Point | Arp2/3 Complex;Actin |
| Passage | Cytoskeleton |
| Background | CK-636 is an Arp2/3 complex inhibitor. |
| Biological Activity | CK-636是具有细胞渗透性的Arp2/3 复合体抑制剂，能抑制肌动蛋白的聚合，对人，裂殖酵母和牛的 IC50 值分别为4 μM，24 μM和32 μM[1]。 |
| In Vitro | CK-636在Arp2和Arp3之间结合，在那里它似乎阻止Arp2和Arp3进入其活性构象。 CK-636插入Arp3的疏水核心并改变其构象。 CK-636可防止肌动蛋白聚合和李斯特菌在感染的SKOV3细胞中形成肌动蛋白丝彗尾(IC50 =22μM)[1]。CK-636处理的T细胞在前缘显示出细长的形态，具有尖锐的伪足，而CK-636处理的T细胞的宽度比DMSO处理的T细胞的宽度小约30％[2]。 |
| Data Literature Source | [1]. Nolen BJ，et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. [2]. Kwon KW，et al. Migration of T cells on surfaces containing complex nanotopography. PLoS One. 2013 Sep 12;8(9):e73960 |
| Unit | Bottle |
| Specification | 5mg 10mg |
CK-636 是一种Arp2/3复合抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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