Sabutoclax
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Cat.No：IS1730 Solarbio
CAS：1228108-65-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Sabutoclax
Product Information
| CAS | 1228108-65-3 |
| Name | Sabutoclax |
| Molecular Formula | C42H40N2O8 |
| Molecular Weight | 700.78 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142645 |
| SMILES | O=C(C1=C(O)C(O)=CC2=C(O)C(C3=C(C)C=C4C(C(NCC(C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NCC(C6=CC=CC=C6)C |
| Target Point | Bcl-2;Bcl-xL;Bfl-1;Mcl-1 |
| Passage | Apoptosis |
| Background | Sabutoclax is a potent and selective inhibitor of the Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1). |
| In Vitro | BI-97C1有效抑制人类前列腺癌，肺癌，和淋巴瘤细胞系生长，EC50值分别为0.13，0.56，和 0.049 μM，对bax-/-bak-/- 细胞几乎没有细胞毒性。[1]说明使用mda-7/IL-24和BI-97C1的联合治疗方案，可诱导自噬，这有利于细胞凋亡，相应地上调NOXA，使Bim累积，并激活Bax和Bak。[2] |
| In Vivo | BI-97C1有效作用于脾B细胞过度表达Bcl-2的转基因小鼠，并对前列腺癌小鼠移植瘤模型具有强效的抗肿瘤效果。[1] Ad.5/3-mda-7 和 BI-97C1处理裸鼠和Hi-myc转基因小鼠，显著抑制人类PC移植瘤和自发诱导的PC的生长。处理PC移植瘤 和Hi-myc小鼠的前列腺，抑制肿瘤生长，与TUNEL染色增加和Ki-67表达降低相关。[2] |
| Animal Experiment | Animal Models: 携带人类前列腺癌移植瘤的Bcl-2转基因小鼠; Dosages: 1 mg/kg，3 mg/kg，5 mg/kg; Administration: 腹腔处理[1] |
| Data Literature Source | [1] Wei J，et al. J Med Chem，2010，53(10)，4166-4176 [2] Dash R，et al. Proc Natl Acad Sci U S A，2011，108(21)，8785- |
| Unit | Bottle |
| Specification | 5mg |
Sabutoclax 是有效的和有选择性的 Bcl-2 Family (Bcl-2， Bcl-XL， Mcl-1， Bfl-1) 抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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