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My CartCAS：313967-18-9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 313967-18-9 |
| Name | FLI-06 |
| Molecular Formula | C25H30N2O5 |
| Molecular Weight | 438.52 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00330996 |
| SMILES | CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4 |
| Target Point | Notch |
| Passage | Stem Cells;Neuronal Signaling |
| Background | FLI-06 is a novel inhibitor targeting the Notch signaling pathway. |
| Biological Activity | FLI-06是Notch信号传导的抑制剂，EC50值为2.3 μM。[1] |
| IC50 | EC50: 2.3μM(Notch signaling)[1] |
| In Vitro | FLI-06以不同于布雷菲德菌素A和golgicide A的方式破坏高尔基体.FLI-06在从内质网退出之前的步骤中抑制一般分泌。在FLI-06处理的细胞中，尽管Aβ分泌强烈减少，但没有APPCTF积累，表明它作用于α-分泌酶和β-分泌酶裂解的上游。 FLI-06是一种非常有用的化学探针，用于研究在没有ER-高尔基体融合的前ER出口部位(ERES)阶段对膜通路的抑制作用[1]。 |
| Kinase Experiment | 测试化合物的EC 50值由系列稀释系列计算，范围为200至0.1μM。将细胞以每孔5，000个细胞的密度接种在96孔板中，在100μL培养基中。第二天，加入含有每种测试化合物的100μL培养基。将细胞温育16小时，固定并加工用于自动显微镜检查。使用包drc [1]的四参数对数逻辑拟合计算EC50估计值。 |
| Data Literature Source | [1]. Kramer A，et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9(11):731-8. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
FLI-06 是一种靶向Notch信号通路的新型抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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