Go 6983
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Cat.No：IG1020 Solarbio
CAS：133053-19-7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > Go 6983
Product Information
| CAS | 133053-19-7 |
| Name | Go 6983 |
| Molecular Formula | C26H26N4O3 |
| Molecular Weight | 442.51 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD04040031 |
| SMILES | O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O |
| InChIKey | LLJJDLHGZUOMQP-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32) |
| PubChem CID | 3499 |
| Target Point | PKC |
| Passage | TGF-beta/Smad;Epigenetics |
| Background | Go 6983 is a potent PKC inhibitor. |
| Biological Activity | Go 6983 是一种有效的 PKC 抑制剂，能够作用于 PKCα，PKCβ，PKCγ，PKCδ 和 PKCζ，IC50 值分别为 7 nM，7 nM，6 nM，10 nM 和 60 nM[1-3]。 |
| In Vitro | Go 6983抑制PKCμ，IC50为20μM，Go 6983可以抑制pther PKC同工酶，IC50值为7~60 nM [1]。与I/R + PMN心脏相比，Go 6983(100 nM)显著降低了PMN对内皮的粘附和向心肌的浸润，并显著抑制了大鼠心脏中PMNs的超氧化物释放90 +/- 2％[2]。与心脏保护性Go 6983浓度(50和100 nM)相比，Go 6983(200 nM)具有降低的心脏保护作用，尽管抑制PMN超氧化物释放99％[3]。 |
| Kinase Experiment | 磷酸化反应在总体积100μL中进行，含有缓冲液C(50mM Tris-HCl，pH7.5，10mMβ-巯基乙醇)，4mM MgCl2，10μgPS，100nM TPA，5μLSf158。细胞提取物作为重组PKCμ或Sf9细胞提取物的来源，作为其他重组PKC同工酶的来源，10μg作为底物的syntide 2，和含有1μCi[γ-32P] ATP的35μMATP。在一些实验中，省略了PS和TPA，或者添加了文中指出的浓度的各种抑制剂。在30℃温育10分钟后，通过将50μL测定混合物转移到20mm见方的磷酸纤维素纸上终止反应，将其在去离子水中洗涤3次并在丙酮中洗涤两次。每种纸上的放射性通过液体闪烁计数确定。 |
| Data Literature Source | [1]. Gschwendt M，et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett，1996，392(2)，77-80. [2]. Peterman EE，et al. G0 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol，2004，43(5)，645-656. [3]. Young LH，et al. G0 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev，2005，23(3)，255-272 |
| Unit | Piece |
| Specification | 5mg |
Go 6983 是一种有效的 PKC 抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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