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My CartCAS：35607-66-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 35607-66-0 |
| Name | Cefoxitin |
| Molecular Formula | C16H17N3O7S2 |
| Molecular Weight | 427.45 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 252-641-2 |
| MDL | MFCD00072014 |
| SMILES | O=C(C(N12)=C(COC(N)=O)CS[C@]2([H])[C@@](NC(CC3=CC=CS3)=O)(OC)C1=O)O |
| Target Point | Antibiotic |
| Passage | Anti-infection |
| Background | Cefoxitin is a broad-spectrum, second-generation cephalosporin with antimicrobial activity. |
| Biological Activity | Cefoxitin 是一种广谱的、具有抗菌活性的第二代头孢菌素。Cefoxitin 对革兰氏阳性/革兰氏阴性需氧菌和厌氧菌引起的各种感染都有效。[1-3] |
| In Vitro | 头孢西丁对革兰氏阳性菌有良好的抗菌活性。几种革兰氏阳性病原体的mic在1-6μg/mL范围内[1]。头孢西丁在浓度为1.25μM/mL时表现出高效杀灭伯氏杆菌[3]。 |
| In Vivo | 头孢西丁(20mg/kg；i.p.；每日；持续5天)可在体内有效杀死布氏杆菌C3H/HeN小鼠模型[3]。动物模型：4周龄雌性C3H/HeN小鼠[3]剂量：20mg/kg给药：腹腔注射，每日一次，连续5天。结果：在体内表现出高效杀灭布氏杆菌的效果。 |
| Data Literature Source | [1]. E O Stapley，et al. Cefoxitin and cephamycins: microbiological studies. Rev Infect Dis. Jan-Feb 1979;1(1):73-89. [2]. R N Brogden，et al. Cefoxitin: a review of its antibacterial activity，pharmacological properties and therapeutic use. Drugs. 1979 Jan;17(1):1-37. [3]. Venkata Raveendra Pothineni，et al. In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. Drug Des Devel Ther. 2018; 12: 2915–2921 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Cefoxitin 是一种广谱的、具有抗菌活性的第二代头孢菌素。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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