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My CartCAS：79307-93-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 79307-93-0 |
| Name | Azelastine Hydrochloride |
| Molecular Formula | C22H24ClN3O·HCl |
| Molecular Weight | 418.36 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 620-469-0 |
| MDL | MFCD00242783 |
| SMILES | O=C1N(C2CCN(C)CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4.Cl |
| InChIKey | YEJAJYAHJQIWNU-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H |
| PubChem CID | 54360 |
| Target Point | Histamine Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | Azelastine hydrochloride is an H1 receptor antagonist. |
| Biological Activity | Azelastine hydrochloridem， an antihistamine， is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis， asthma， diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4]. |
| IC50 | H1 Receptor |
| In Vitro | Azelastine hydrochloride can significantly inhibit HNEpC proliferation， and therefore， be helpful in against airway remodeling[5]. |
| In Vivo | Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose， HbA1c and serum alkaline phosphatase (ALP)， osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model[2].Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model[2].Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model[2]. |
| Data Literature Source | [1]. Craig La Force. Review of the pharmacology，clinical efficacy，and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1(2):191-201. [2]. Mohamed M Elseweidy，et al. Azelastine a potent antihistamine agent，as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8. [3]. Carlos D. Zappia，et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7(6): e00531. [4]. Li Yang，et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1–7. [5]. Shao-Cheng Liu，et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):845-853. |
| Unit | Piece |
| Specification | 100mg 200mg 500mg |
Azelastine盐酸盐是H1受体拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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