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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ASLAN003CAS：1035688-66-4
Molecular Formula：C19H14F2N2O3
Molecular Weight：356.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1035688-66-4 |
| Name | ASLAN003 |
| Molecular Formula | C19H14F2N2O3 |
| Molecular Weight | 356.32 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| SMILES | COC1=CC=CC(=C1)C2=CC(=C(C(=C2)F)NC3=C(C=CC=N3)C(=O)O)F |
| InChIKey | OMPATGZMNFWVOH-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H14F2N2O3/c1-26-13-5-2-4-11(8-13)12-9-15(20)17(16(21)10-12)23-18-14(19(24)25)6-3-7-22-18/h2-10H,1H3,(H,22,23)(H,24,25) |
| PubChem CID | 24986824 |
| Target Point | Dihydroorotate dehydrogenase (DHODH) |
| Passage | Metabolic Enzyme&Protease |
| Background | Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. [1] |
| In Vitro | IC50: 35 nM (human DHODH enzyme)[1] |
| In Vivo | Farudodstat (1， 2 μM; pretreatment 1 h before OPP for 1 h) inhibits protein synthesis， as demonstrated by the reduced incorporation of O-propargyl-puromycin (OPP) at protein translation sites in both MOLM-14 and KG-1 cells. Farudodstat causes the downregulation of EIF4B， and RPL6 proteins[1]. |
| Cell Experiment | Farudodstat (50 mg/kg; oral gavage; once daily; from the day 3 to 30) substantially reduces the number of disseminated tumors and prolongs survival[1]. |
| Unit | Piece |
| Specification | 5mg |
是DHODH的新型，有效且口服可生物利用的抑制剂，可用于AML（急性骨髓性白血病）的相关研究。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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