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My CartCAS：39809-25-1
Molecular Formula：C10H15N5O3
Molecular Weight：253.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 39809-25-1 |
| Name | Penciclovir |
| Molecular Formula | C10H15N5O3 |
| Molecular Weight | 253.26 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 663-371-3 |
| MDL | MFCD00866931 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2CCC(CO)CO |
| InChIKey | JNTOCHDNEULJHD-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18) |
| PubChem CID | 135398748 |
| Target Point | HSV |
| Passage | Anti-infection |
| Background | Penciclovir is effective against HSV1 and 2. |
| Biological Activity | Penciclovir 有效作用于 HSV1 和 2，IC50 分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。[1-2] |
| IC50 | 0.04-1.8μg/mL(HSV-1)，0.06-4.4μg/mL(HSV-2)，1.6-8μg/mL(VZV)，1.5-3.1μg/mL(EBV)，51μg/mL(HCMV)[1] |
| In Vitro | 喷昔洛韦抑制单纯疱疹病毒1型(HSV-1)和2型(HSV-2)，水痘 - 带状疱疹病毒(VZV)，epstein-Barr病毒(EBV)，人巨细胞病毒(HCMV)，IC50为0.04-1.8μg/分别为mL，0.06-4.4μg/ mL，1.6-8μg/ mL，1.5-3.1μg/ mL，51μg/ mL。喷昔洛韦(PCV)是一种非环状鸟嘌呤衍生物(其作为口服剂不能商购)，具有与阿昔洛韦(ACV)类似的活性谱和作用机制[1]。 |
| Cell Experiment | 将人乳腺癌细胞系MCF-7和MDA-MB-435，成胶质细胞瘤U87MG和胚胎肾细胞293T在含有5％CO 2的潮湿气氛中在Iscove改良的Dulbecco培养基或Leibovitz L-培养基中培养，并且5％胎牛血清(FBS)。稍微修改进行测定。简而言之，将细胞接种到24孔板(5×104细胞/孔)中，并在48小时后用每个细胞103个颗粒的未修饰病毒(Adtk)，聚乙二醇化病毒(PEG-Adtk)或RGD-PEG修饰的细胞进行感染。病毒(RGD-PEG-Adtk)在含有2％FBS的培养基中一式三份，并在37℃温育4小时。然后用常规培养基替换培养基，并将细胞进一步培养48小时。收获细胞并用500μL含有0.5％Nonidet P-40(NP-40)，20mM N-(2-羟乙基)哌嗪-N' -(2-乙磺酸)(HEPES)的TK裂解缓冲液裂解(pH 7.6)，2mM Mg(OAc)2，1mM二硫苏糖醇和50μM胸苷。离心后收集上清液。将样品保持在-80℃直至使用。通过Micro BCA测定法测定修饰的和未修饰的腺病毒蛋白浓度。将1微克细胞提取物与HSV1-tk底物8-3H-喷昔洛韦(8-3H-PCV)一起温育。用DE-81过滤器将磷酸化的示踪剂与未磷酸化的8-3H-PCV分离。 TK活性表示为每微克蛋白质每分钟底物转化的百分比[2]。 |
| Data Literature Source | [1]. Piret J，et al. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms，prevalence，and management. Antimicrob Agents Chemother. 2011 Feb;55(2):459-72. [2]. Xiong Z，et al. Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living micewith mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med. 2006 Jan;47(1):130-9. |
| Unit | Bottle |
| Specification | 50mg 100mg 500mg |
Penciclovir 有效作用于 HSV1 和 2。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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