{{cart_num}}
My CartCAS：87848-99-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 87848-99-5 |
| Name | Acrivastine |
| Molecular Formula | C22H24N2O2 |
| Molecular Weight | 348.44 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00869830 |
| SMILES | O=C(O)/C=C/C1=NC(/C(C2=CC=C(C)C=C2)=C/CN3CCCC3)=CC=C1 |
| Target Point | Histamine Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | Acravastine/BW825C is a histamine 1 receptor antagonist. |
| Biological Activity | Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.[1-2] |
| In Vivo | Acrivastine(usually 8mg three times daily)is an effective and well tolerated antihistamine in the treatment of chronic urticaria and allergic rhinitis. Acrivastine is more effective than placebo and similar in efficacy to clemastine or terfenadine in the treatment of seasonal allergic rhinitis. In the treatment of dermatoses in which histamine has a pathogenetic role，the efficacy of acrivastine is superior to that of placebo and similar to that of usual dosages of clemastine，hydroxyzine，chlorpheniramine，cyproheptadine or terfenadine. Acrivastine causes less drowsiness than clemastine，the incidence of adverse effects being indistinguishable from that with placebo or terfenadine[1]. Both 4 mg and 8 mg acrivastine alleviate the symptoms of seasonal allergic rhinitis with significant improvements in the symptom scores for sneezing，running nose and the calculated overall score. In addition，8 mg acrivastine reduces the symptom scores for watery eyes and itchy throat. Acrivastine is both well tolerated and effective in the treatment of seasonal allergic rhinitis[2]. |
| Data Literature Source | [1]. Brogden RN，et al. Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis，urticaria and related disorders. Drugs. 1991 Jun;41(6):927-40. [2]. Gibbs TG，et al. Acrivastine in two doses compared with placebo in a multicentre，parallel group study for the treatment of seasonal allergic rhinitis. Br J Clin Pract. 1989 Jan;43(1):11-4 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
是histamine 1受体拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
