{{cart_num}}
My CartCAS：645-05-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 645-05-6 |
| Name | Altretamine |
| Molecular Formula | C9H18N6 |
| Molecular Weight | 210.28 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 211-428-4 |
| MDL | MFCD00549245 |
| SMILES | CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 |
| InChIKey | UUVWYPNAQBNQJQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3 |
| PubChem CID | 2123 |
| Target Point | DNA Alkylator |
| Passage | DNA Damage/DNA Repair |
| Background | Altretamine is an alkylator. |
| Biological Activity | Altretamine 是一种烷化剂 (alkylator)，具有抗肿瘤活性[1]。 |
| In Vivo | Altretamine(100，133 mg/kg，ip。)与Irofulven联合使用可增加携带MV522细胞的小鼠的抗肿瘤作用[1]。 |
| Animal Experiment | 小鼠[1] Balb/c nu/nu 4周龄雌性小鼠体重18-22g，接受sc注射8-10百万MV522细胞。在肿瘤植入后第10天开始，每周三次腹膜内施用阿尔特雷明，持续3周。以两个垂直直径测量肿瘤大小，并根据下式估计肿瘤重量(TW)：w = [(宽度)2×长度/ 2]。将阿尔特赖胺制备成在40％DMSO /生理盐水中的1-10mg/mL的储备溶液，并根据需要用10％DMSO /生理盐水稀释[1]。 |
| Data Literature Source | [1]. Kelner MJ，et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine，alkylating，and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26. |
| Unit | Bottle |
| Specification | 100mg 500mg |
Altretamine 是一种烷化剂 (alkylator)。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
