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My CartCAS：15686-71-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 15686-71-2 |
| Name | Cefalexin |
| Molecular Formula | C16H17N3O4S |
| Molecular Weight | 347.39 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 239-773-6 |
| MDL | MFCD04966776 |
| SMILES | O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O |
| InChIKey | ZAIPMKNFIOOWCQ-UEKVPHQBSA-N |
| InChI | InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1 |
| PubChem CID | 27447 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Cefalexin is a cephalosporin antibiotic. |
| Biological Activity | Cephalexin is a potent, orally active and the first-generation cephalosporin antibiotic. Cephalexin kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall[1-2]. |
| In Vivo | After a single intravenous administration of cephalexin(5 mg/kg)，Mate1(-/-)mice showed higher plasma concentrations of cephalexin than wild-type [Mate1(+/+)] mice. The urinary excretion of cephalexin for 60 min was significantly reduced，and the renal concentration was markedly increased in Mate1(-/-)mice compared with Mate1(+/+)mice. The renal clearance of cephalexin in Mate1(-/-)mice was approximately 60% of that in Mate1(+/+)mice and seemed to be near the creatinine clearance.[1] Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands，and inhibits the activity of cervix mucous cells. A simultaneous administration of ethanol and cephalexin causes atrophic changes in gastric glands，and thereby strong reduction of mucous cells activity.[2] |
| Animal Experiment | The Wistar rat males weighing approximately 200 g were administered 20% ethanol ad libitum during 10 days，cephalexin in the dose of 42 mg/24 h，and simultaneously ethanol and cephalexin in the above-mentioned doses. After 10 days the animals were decapitated and stomach specimens were taken from the major curvature region for examinations. [2] |
| Data Literature Source | [1] Watanabe S，et al. J Pharmacol Exp Ther，2010，334(2)，651-656. [2] Zarebska A，et al. Ann Univ Mariae Curie Sklodowska Med，2004，59(1)，145-150. |
| Unit | Bottle |
| Specification | 500mg 1g 5g |
Cefalexin是头孢菌素类抗生素。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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