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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > LevetiracetamCAS：102767-28-2
Molecular Formula：C8H14N2O2
Molecular Weight：170.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 102767-28-2 |
| Name | Levetiracetam |
| Molecular Formula | C8H14N2O2 |
| Molecular Weight | 170.21 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-659-6 |
| MDL | MFCD03265610 |
| SMILES | NC([C@@H](N(CCC1)C1=O)CC)=O |
| Target Point | mAChRs (muscarinic acetylcholine receptors) Calcium Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling;GPCR & G Protein |
| Background | Levetiracetam/UCB L059 is a potent and selective M2 muscarinic acetylcholine receptor (mAChR) inhibitor |
| Biological Activity | Levetiracetam， an antiepileptic agent， binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT， thus increasing Temozolomide effectiveness. A chemosensitizer agent[1-2]. |
| In Vitro | Levetiracetam sensitizes(40 μg/mL)glioblastoma multiforme stem-like cells(GSCs)to Temozolomide(250 μM)treatment[1]. |
| In Vivo | Levetiracetam(10，25，or 50 mg/kg)suppresses behavioral and electrographic seizure activity during neonatal hypoxia[2]. |
| Data Literature Source | [1]. Bianca Maria Scicchitano，et al. Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Cancer Cell Int. 2018 Sep 10;18:136. [2]. Delia M Talos，et al. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013 Jan;73(1):24-30. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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