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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Fluvoxamine maleateCAS：61718-82-9
Molecular Formula：C14H18F3N2O2·C4H4O4
Molecular Weight：434.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 61718-82-9 |
| Name | Fluvoxamine maleate |
| Molecular Formula | C14H18F3N2O2·C4H4O4 |
| Molecular Weight | 434.41 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 228-994-3 |
| MDL | MFCD00269809 |
| SMILES | O=C(O)/C=C\C(O)=O.FC(C1=CC=C(/C(CCCCOC)=N/OCCN)C=C1)(F)F |
| Target Point | 5-HT Receptor;Serotonin Transporter (SERT) |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a serotonin reuptake inhibitor. |
| Biological Activity | Fluvoxamine maleate (DU-23000, MK-264)是一种选择性5-羟色胺再摄取抑制剂(SSRI)。[1] |
| In Vitro | Fluvoxamine增加大鼠前额皮质和丘脑中[5-HT]的水平，也增加纹状体中[DA]的水平。[1] Fluvoxamine maleate可通过脊柱5-HT 2A/2C受体改善触觉异常性疼痛，通过作用于受体或5-HT的神经元起作用。[2] |
| In Vivo | 在非结扎小鼠的爪压力测试中，Fluvoxamine maleate也表现出剂量依赖方式的抗伤害感受。Fluvoxamine maleate也诱导急性爪压力测试的抗伤害作用，并且这种作用为5-HT3受体拮抗剂granisetron所拮抗。[2] 在大鼠海马内侧前额叶皮质(mPFC)中，Fluvoxamine(10和30 mg/kg，腹腔注射)以剂量依赖的方式增强了海马-mPFC通路突触效能。[3] 在麻醉大鼠的海马CA1区中，Fluvoxamine(10和30 毫克/千克，腹腔注射)抑制长时程增强(LTP)。Fluvoxamine(30 毫克/千克，腹腔注射)诱导的LTP为5-HT(1A)受体拮抗剂NAN-190(0.5 毫克/千克，腹腔注射)完全逆转，但不是受5-HT(4)受体拮抗剂GR113808(20 毫克/大鼠，脑室注射)以及5-HT的(7)受体拮抗剂DR4004(10 毫克/大鼠，脑室注射)所影响。[4] |
| Cell Experiment | Fluvoxamine maleate(10 and 30 mg/kg，i.p.)dose-dependently elevated the 50% threshold，as assessed by the von Frey test. At a dose of 30 mg/kg，the antiallodynic effects of fluvoxamine were significant and the 50% threshold was elevated to 0.19 _x0003_ 0.05 g at 15 min after its administration. On the other hand，the tricyclic antidepressant amitriptyline hydrochloride(3 and 10 mg/kg，s.c.)did not exert antiallodynic effects in Seltzer-model mice. Because amitriptyline showed the muscle relaxant effect via 5-HT2 receptors，effects of the higher dose of amitriptyline were not determined. Fluvoxamine was injected either i.c.v. or i.t. to determine the site of its antiallodynic effect. While i.c.v. injection of fluvoxamine maleate(10，30，and 100 mg/animal)did not show any effects on the withdrawal threshold，i.t. injection(10，30，and 100 mg/animal)induced the antiallodynic effect. These results indicate that the antiallodynic effect of i.p. fluvoxamine is produced at the spinal cord.[2] |
| Data Literature Source | [1] Denys D，et al. Psychopharmacology (Berl)，004，176(2)，195-203. [2] Honda M，et al. Neuropharmacology，2006，51(4)，866-872. [3] Ohashi S，et al. Brain Res，2002，949(1-2)，131-138. [4] Kojima T，et al. Brain Res，2003，959(1)，165-168. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
是5-羟色胺再吸收抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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