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My CartCAS：91832-40-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Light yellow to yellow Solid
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| CAS | 91832-40-5 |
| Name | Cefdinir |
| Molecular Formula | C14H13N5O5S2 |
| Molecular Weight | 395.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 643-088-1 |
| MDL | MFCD00865030 |
| SMILES | O=C(C(N12)=C(C=C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\O)=O)C1=O)O |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Cefdinir is a broad-spectrum antimicrobial. |
| Biological Activity | Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin[1-2]. |
| In Vitro | Cefdinir，一个新的口服2-氨基-5-噻唑基头孢菌素，以浓度依赖性方式但不是时间依赖性方式，抑制由PMA刺激的人嗜中性粒细胞的luminol放大的化学发光(LACL)反应，但不是opsonized zymosan。在过氧化氢，碘化钠组成的无细胞系统中，以及包含辣根过氧化物酶或含amyeloperoxidase的中性粒细胞的提取物中，Cefdinir抑制LACL的产生。Cefdinir损害钙离子载体A23187和FMLP诱导的LACL反应，而这种损害在细胞松弛素B处理的中性粒细胞中增多。在可溶性介质刺激的中性粒细胞中，Cefdinir直接抑制包含myeloperoxidase的中性粒细胞提取物释放到细胞外基质的活性，Cefdinir不影响吞噬作用过程中释放到吞噬溶酶体。[1] Cefdinir对众多革兰氏阳性和革兰氏阴性细菌具有优良的活性。Cefdinir对各种各样的β内酰胺酶有抗性并表现出β内酰胺稳定性轮廓，通常效果比cefaclor和cefuroxime更好。Cefdinir主要由肾脏介导清除。Cefdinir与二肽转运PEPT1和PEPT2结合。Cefdinir肾小管重吸收是实质性的，即头孢地尼肾小管分泌可以被probenecid抑制，并且这种分泌可能是由肾有机阴离子分泌途径介导的。[2] |
| Data Literature Source | [1] Labro MT，et al. J Immunol，1994，152(5)，2447-2455. [2] Lepsy CS，et al. Antimicrob Agents Chemother，2003，47(2)，68 |
| Unit | Bottle |
| Specification | 500mg 1g |
Cefdinir是广谱抗菌剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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