BMS-707035
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Cat.No：IB0900 Solarbio
CAS：729607-74-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Solid
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
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MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| CAS | 729607-74-3 |
| Name | BMS-707035 |
| Molecular Formula | C17H19FN4O5S |
| Molecular Weight | 410.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18074518 |
| SMILES | FC1=CC=C(C=C1)CNC(C(N=C(N2C)N3S(CCCC3)(=O)=O)=C(C2=O)O)=O |
| Target Point | HIV |
| Passage | Anti-infection |
| Background | BMS-707035 is an HIV-1 integrase inhibitor. |
| Biological Activity | BMS-707035是一种特异性的HIV-I integrase (IN)（整合酶）抑制剂，IC50为15 nM。[1] |
| IC50 | HIV-I integrase: 15nM[1] |
| In Vitro | BMS-707035和靶点DNA与IN结合是互斥的，通过增加靶点 DNA量而克服BMS-707035对链转移催化的抑制反应。BMS-707035 与IN的结合亲和力也受预加工的 U5 长末端重复序列(LTR)处的四个末端碱基影响。IN的Gln148 BMS-707035与 IN的结合的关键。[1] |
| Data Literature Source | [1] Dicker IB，et al. J Biol Chem，2007，282(43)，31186-31196. |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
BMS-707035是HIV-1整合酶抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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