{{cart_num}}
My CartCAS：57852-57-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 57852-57-0 |
| Name | Idarubicin Hydrochloride |
| Molecular Formula | C26H27NO9·HCl |
| Molecular Weight | 533.95 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 260-990-7 |
| MDL | MFCD00897212 |
| SMILES | OC(C(C(C1=CC=CC=C21)=O)=C3C2=O)=C4[C@H](C[C@@](C(C)=O)(O)CC4=C3O)O[C@@](O[C@@H](C)[C@H]5O)([H])C[C@@H]5N.Cl |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | ICI 118,551 hydrochloride is a highly selective β2 adrenergic receptor antagonist. |
| Biological Activity | Idarubicin hydrochloride是一种蒽环类抗白血病试剂。 它抑制 拓扑异构酶II，干扰DNA复制和RNA转录。[1-4] |
| In Vitro | 伊达比星的IC50在MCF-7单层上为3.3±0.4 ng / mL，在多细胞球体中为7.9±1.1 ng / mL [1]。在各种体外系统中，Idarubicin比柔红霉素或多柔比星显示出更大的细胞毒性。这归因于伊达比星更好地诱导拓扑异构酶II介导的DNA断裂的形成[2]。伊达比星的活性分别比阿霉素和表柔比星高约57.5倍和25倍[3]。 Idarubicin产生浓度依赖性细胞生长减少，IC50值约为0.01μM。 Idarubicin产生浓度依赖性的DNA合成抑制[4]。 |
| Cell Experiment | 将盐酸伊达比星的储备溶液溶解在蒸馏水(1mg / mL)中。将MCF-7单层以0.01，0.1，1，10，100和1000ng / mL暴露于伊达比星或其代谢物伊达比星，持续24小时。多细胞球体暴露于相同范围的伊达比星和伊达比星浓度单层(0.01-1000 ng / mL)24小时，并且在单独的实验中，药物浓度为100 ng / mL，持续6，12，24和48小时。通过用血细胞计数器计数活细胞来确定细胞增殖的抑制。结果表示为细胞存活与对照培养物的百分比[1]。 |
| Data Literature Source | [1]. Orlandi P， et al. Idarubicin and idarubicinol effects on breast cancer multicellular spheroids. J Chemother. 2005 Dec; 17 (6) :663-7. [2]. Robert J. Clinical pharmacokinetics of idarubicin. Clin Pharmacokinet. 1993 Apr; 24 (4) :275-88. [3]. Siegsmund MJ， et al. Enhanced in vitro cytotoxicity of idarubicin compared to epirubicin and doxorubicin in rat prostate carcinoma cells. Eur Urol. 1997; 31 (3) :365-70. [4]. Gewirtz DA， et al. Induction of DNA damage， inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog， idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line. Cancer Chemother Pharmacol. 1998; 41 (5) :361 |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Idarubicin hydrochloride抑制拓扑异构酶II，干扰DNA复制和RNA转录，可用于白血病方向的研究。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
