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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > 1-Caffeoylquinic acidCAS：1241-87-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1241-87-8 |
| Name | 1-Caffeoylquinic acid |
| Molecular Formula | C16H18O9 |
| Molecular Weight | 354.31 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD10566609 |
| SMILES | O[C@@H]1[C@H](O)C[C@@](OC(/C=C/C2=CC(O)=C(O)C=C2)=O)(C(O)=O)C[C@H]1O |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | 1-Caffeoylquinic acid is a potent NF-κB inhibitor, showing significant binding affinity to the RH domain of p105. Has anti-oxidative stress ability. Inhibits PD-1/PD-L1 interaction. |
| Biological Activity | 1-Caffeoylquinic acid is an effective NF-κB inhibitor， shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact[3]. |
| Data Literature Source | [1]. Khan MK，et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7. [2]. Jiang Y，et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320. [3]. Han Y，et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56. |
| Unit | Bottle |
| Specification | 5mg 10mg |
是一种有效的NF-κB抑制剂，对p105的RH结构域显示出显著的结合亲和力。具有抗氧化应激能力。抑制PD-1/PD-L1相互作用。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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