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Deforolimus

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Cat.No：ID1040 Solarbio

CAS：572924-54-0

Molecular Formula：C₅₃H₈₄NO₁₄P

Molecular Weight：990.21

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	572924-54-0
Name	Deforolimus
Molecular Formula	C₅₃H₈₄NO₁₄P
Molecular Weight	990.21
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD13184816
SMILES	O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@@H]4C[C@H]([C@H](OP(C)(C)=O)CC4)OC)C)=O)=O
Target Point	mTOR
Passage	PI3K/Akt/mTOR
Background	Deforolimus/MK-8669 is a potent and selective mTOR inhibitor.
Biological Activity	Deforolimus 是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6磷酸化的 IC50 值为 0.2 nM。[1-2]
Data Literature Source	[1]. Rivera VM， et al. Deforolimus (AP23573; MK-8669) ， a potent mTOR inhibitor， has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Mol Cancer Ther. 2011 Jun; 10 (6) :1059-71. [2]. Brandt M， et al. mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. Cell Metab. 2018 Jan 9; 27 (1) :118-135.e8.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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