{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > DactolisibCAS：915019-65-7
Molecular Formula：C30H23N5O
Molecular Weight：469.55
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 915019-65-7 |
| Name | Dactolisib |
| Molecular Formula | C30H23N5O |
| Molecular Weight | 469.55 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD00005880 |
| SMILES | CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O |
| Target Point | PI3K;mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | BEZ235 is a dual pan-class I PI3K and mTOR inhibitor. |
| Biological Activity | BEZ235 是一种双重的 pan-class I PI3K 和 mTOR 抑制剂，作用于 p110α/γ/δ/β 和 mTOR，IC50 分别为 4 nM/5 nM/7 nM/75 nM 和 20.7 nM。BEZ235 抑制 mTORC1 和 mTORC2[1-3]。 |
| Data Literature Source | [1]. Maira SM，et al. Identification and characterization of NVP-BEZ235，a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther，2008，7(7)，1851-1863. [2]. Roper J，et al. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS One，2011，6(9)，e25132. [3]. Lee M，et al. Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas. Clin Cancer Res. 2015 Jul 15;21(14):3204-15 |
| Unit | Bottle |
| Specification | 10mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
