Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > Bosutinib

Bosutinib

Manual Download

Cat.No：IB0740 Solarbio

CAS：380843-75-4

Molecular Formula：C₂₆H₂₉Cl₂N₅O₃

Molecular Weight：530.45

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥99%

Appearance：White to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	380843-75-4
Name	Bosutinib
Molecular Formula	C₂₆H₂₉Cl₂N₅O₃
Molecular Weight	530.45
Solubility	Soluble in DMSO
Purity	≥99%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 700-455-1
MDL	MFCD07367846
SMILES	CN1CCN(CC1)CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC
Target Point	Src;Abl
Passage	Protein Tyrosine Kinase/RTK
Background	Bosutinib is a dual inhibitor of Src/Abl.
Biological Activity	Bosutinib（SKI-606） is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.[1]
IC50	Src: 1.2nM;Abl: 1nM[1]
Data Literature Source	[1]. Boschelli DH，et al. Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. J Med Chem，2001，44(23)，3965-3977. [2]. Vultur A，et al. SKI-606 (bosutinib)，a novel Src kinase inhibitor，suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther，2008，7(5)，1185-1194. [3]. Golas JM，et al. SKI-606，a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models. Cancer Res，2005，65(12)，5358-5364.
Unit	Bottle
Specification	10mg 20mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.