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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > CedrolCAS：77-53-2
Molecular Formula：C15H26O
Molecular Weight：222.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：GC≥98%
Appearance：White to off-white Solid
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| CAS | 77-53-2 |
| Name | Cedrol |
| Molecular Formula | C15H26O |
| Molecular Weight | 222.37 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | GC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-035-6 |
| MDL | MFCD00062952 |
| SMILES | O[C@]1(C)CC[C@@]23[C@H](C)CC[C@@]2([H])C(C)(C)[C@@]1([H])C3 |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | Cedrol is a biologically active sesquiterpene, a potent cytochrome P-450 (CYP) enzyme competitive inhibitor. |
| Biological Activity | Cedrol is bioactive sesquiterpenes found in cedar essential oil and exert antiseptic, anti-inflammatory, antispasmodic, tonic, astringent, diuretic, sedative, insecticidal, and antifungal activities. Cedrol was found to be potent competitive inhibitors of CYP2B6-mediated bupropion hydroxylase . [1-3] |
| In Vitro | Cedrol is an anti-inflammatory constituent，anti-microbial ingredient and antibiosis agent[1]. Cedrol could accelerate fibroblast growth in a dose-dependent manner and increase the production of type 1 collagen and elastin. Phosphorylation of p42/44 extracellular signal-regulated kinase，p38 mitogen-activated protein kinase，and Akt are also markedly increased by the treatment of cedrol，indicating that cedrol stimulates ECM production[3]. Cedrol is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant(Ki)value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8，CYP2C9，and CYP2C19 activities[2]. |
| In Vivo | Cedrol can promote hair reproduction. It promotes hair regeneration and shortens the telogen phase of hair follicles after alopecia occurs. Cedrol may possess a latent ability of preventing damage to initiatory hair follicle and restoring the morphological characteristics of follicles after they have been damaged by chemotherapy. Cedrol is a PAF(platelet-activating factor)antagonist that can reduce or inhibit platelet aggregation，skin inflammation，and vascular disorders[1]. |
| Data Literature Source | [1] Chen SS，et al. Environ Toxicol Pharmacol. 2016，46:270-276. [2] Jeong HU，et al. J Toxicol Environ Health A. 2014，77(22-24):1522-32. [3] Jin MH，et al. Ann Dermatol. 2012，24(1):16-21. |
| Unit | Piece |
| Specification | 20mg 50mg 100mg |
Cedrol 是一种生物活性倍半萜，一种有效的细胞色素 P-450(CYP) 酶竞争性抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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