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My CartCAS：91161-71-6
Molecular Formula：C21H25N
Molecular Weight：291.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 91161-71-6 |
| Name | Terbinafine |
| Molecular Formula | C21H25N |
| Molecular Weight | 291.43 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-385-8 |
| MDL | MFCD00242672 |
| SMILES | CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1 |
| InChIKey | DOMXUEMWDBAQBQ-WEVVVXLNSA-N |
| InChI | InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+ |
| PubChem CID | 1549008 |
| Target Point | Fungal |
| Passage | Anti-infection |
| Background | It is an allylamine antifungal compound, which inhibits squalene cyclooxygenase in the process of ergosterol synthesis in fungal cells, and enables squalene to accumulate in cells and play a bactericidal role. |
| Biological Activity | Terbinafine (TDT 067) 是治疗真菌感染的抗真菌药物。它是来自念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂， Ki值为30 nM。[1-2] |
| IC50 | Ki: 30nM(squalene epoxidase)[1] |
| Data Literature Source | [1]. Ryder NS，et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7. [2]. Mieth H，et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-7. |
| Unit | Piece |
| Specification | 100mg 10mM*1mL in DMSO 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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