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My CartCAS：82410-32-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 82410-32-0 |
| Name | Ganciclovir |
| Molecular Formula | C9H13N5O4 |
| Molecular Weight | 255.23 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ≥1mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 627-054-3 |
| MDL | MFCD00870588 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2COC(CO)CO |
| Target Point | HSV |
| Passage | Anti-infection |
| Background | Ganciclovir is a potent herpes simplex virus (HSV) inhibitor. |
| Biological Activity | Ganciclovir 是有效的单纯疱疹病毒 (HSV) 抑制剂，包括巨细胞病毒（CMV），抑制FHV-1的 IC50 值为5.2 μM 。[1-4] |
| IC50 | 5.2μM(FHV-1)[1] |
| In Vitro | 更昔洛韦是一种非环状脱氧鸟苷类似物，其结构与阿昔洛韦相似，但具有优异的抗CMV活性。抑制病毒复制50％所需的更昔洛韦中位数浓度为2.15 mumol，而阿昔洛韦为72 mumol [2]。更昔洛韦对CMV的作用的主要机制是抑制ganciclovir-5'-triphosphate(更昔洛韦)对病毒DNA的复制。 TP)。这种抑制包括对病毒DNA聚合酶的选择性和有效抑制。更昔洛韦主要通过三种细胞酶代谢成三磷酸形式：由CMV感染细胞诱导的脱氧鸟苷激酶;鸟苷酸激酶;和磷酸甘油酸激酶[3]。 |
| In Vivo | 在成年大鼠中，更昔洛韦的耳蜗内扩散显示出与血液中相同的浓度。在妊娠小鼠中，观察到经胎盘扩散，胎儿与母体的血液比率为0.5。在新生小鼠中，更昔洛韦的血浆浓度曲线在2小时显示峰值，然后逐渐减少。在成年小鼠中，浓度在1小时达到峰值，但在注射后2小时变得不可检测。在更昔洛韦治疗的新生小鼠中，白细胞，红细胞和血小板的数量显著减少[4]。 |
| Animal Experiment | 大鼠：在该研究中使用两只未经MCMV免疫的白化大鼠。称重后，两只成年大鼠进行腹膜注射。第一只大鼠每天两次(即100mg/kg /天)接受50mg/kg更昔洛韦，总共3天或6次注射。第二只大鼠用作阴性对照并接受腹膜内注射葡萄糖溶液。第6次注射后，处死两只大鼠;收集血液和外淋巴液进行分析[4]。小鼠：非近交的Oncins法国1(OF1)小鼠用于该研究。更昔洛韦在5％葡萄糖血清中稀释至浓度为5mg/mL，并以50mg/kg的剂量腹膜内给予新生小鼠，每天两次。总共进行五次注射[4]。 |
| Data Literature Source | [1]. Maggs DJ，et al. In vitro efficacy of ganciclovir，cidofovir，penciclovir，foscarnet，idoxuridine，and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [2]. Fletcher CV，et al. Evaluation of ganciclovir for cytomegalovirus disease. DICP. 1989 Jan;23(1):5-12. [3]. Matthews T，et al. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4. [4]. BoujemLa I，et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5. |
| Unit | Piece |
| Specification | 100mg 10mM*1mL in DMSO 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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