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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > 4'-DemethylepipodophyllotoxinCAS：6559-91-7
Molecular Formula：C21H20O8
Molecular Weight：400.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 6559-91-7 |
| Name | 4'-Demethylepipodophyllotoxin |
| Molecular Formula | C21H20O8 |
| Molecular Weight | 400.38 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 613-823-0 |
| MDL | MFCD00189421 |
| SMILES | O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H] |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | It inhibits microtubule assembly. |
| Biological Activity | 生物活性 改为 4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly. [1]. |
| IC50 | 0.31uM(EC5 0in HL60 cell，mTT assay，48h);0.37uM(EC50 in HepG2 cell，mTT assay，48h) [1] |
| Data Literature Source | [1]. Tang YJ，Zhao W，Li HM. Novel tandem biotransformation process for the biosynthesis of a novel compound，4-(2，3，5，6-tetramethylpyrazine-1)-4'-demethylepipodophyllotoxin. Appl Environ Microbiol. 2011 May;77(9):3023-34. |
| Unit | Piece |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
能抑制微管组装。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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