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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Bacterial > Ciprofloxacin HCLCAS：86393-32-0
Molecular Formula：C17H18FN3O3·HCl·H2O
Molecular Weight：385.82
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 86393-32-0 |
| Name | Ciprofloxacin HCL |
| Molecular Formula | C17H18FN3O3·HCl·H2O |
| Molecular Weight | 385.82 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 617-845-1 |
| MDL | MFCD00242856 |
| SMILES | O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O.[H]Cl.O |
| InChIKey | ARPUHYJMCVWYCZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2 |
| PubChem CID | 62998 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Ciprofloxacin hydrochloride is an antibiotic with potent antibacterial activity. |
| Biological Activity | Ciprofloxacin hydrochloride 是一种氟喹诺酮类抗生素，具有高效的抗菌活性。[1-3] |
| In Vitro | 环丙沙星(盐酸一水合物)是一种氟喹诺酮类抗生素，具有强大的抗菌活性[1]。环丙沙星(盐酸一水合物)(CIP)对鼠疫杆菌具有强效活性，MIC90为0.03μg/mL[2]。 |
| In Vivo | 环丙沙星(盐酸盐一水合物)(1mg/L)诱导谷胱甘肽-S-转移酶(GST)活性，与暴露于恩诺沙星的幼虫的抑制GST和过氧化氢酶(CAT)相反。环丙沙星(盐酸一水合物)(≥10μg/L)对两栖动物幼虫的发育、生长、解毒和氧化应激酶具有生态毒性[1]。在肺鼠疫的小鼠模型中，环丙沙星(盐酸一水合物)(30mg/kg，i.p.)导致药物暴露，其类似于500mg口服环丙沙星(盐酸一水合物)后在人体中观察到的药物暴露。腹腔注射环丙沙星(盐酸一水合物)比腹腔注射PBS治疗的对照组降低肺部细菌负荷[3]。 |
| Cell Experiment | 通过在绵羊血琼脂(SBA)平板上悬浮菌落至18至24小时(炭疽杆菌)或42至48小时(鼠疫杆菌)到Mueller-Hinton肉汤(CAMHB)(含有环丙沙星(盐酸一水合物))中制备细菌接种物，所述绵羊血琼脂(SBA)平板在35℃下孵育。用CAMHB稀释悬浮培养物至细菌细胞密度为105CFU/mL。根据600nm处的光密度进行调整。向96孔板的每个孔中加入50μL稀释液，最终接种量为~5×104CFU/孔。平板在35°C下孵育。在18至24小时(炭疽杆菌)或42至48小时(鼠疫杆菌)视觉测定MIC，并通过600nm处的吸光度测定MIC[2]。 |
| Animal Experiment | 在该测定中使用8-10周龄和20g(±4g)的雌性BALB/cAnNCrl(BALB/c)小鼠。通过腹膜内(i.p.)途径向小鼠(n=30)施用单剂量环丙沙星(盐酸一水合物)(30mg/kg)。给药环丙沙星(盐酸一水合物)后1，10，20或30分钟和1，1.5，2，4，8，12小时以及给药DRCFI或CFI后1，15或30分钟和1，2，4，6，10，18或24小时处处死小鼠(n=3/时间点/组)。根据环丙沙星(盐酸一水合物)的短半衰期和CFI的长半衰期选择血液采样点。死后收集血液和肺(整个器官)进行分析。使用给药后1分钟肺样品中环丙沙星(盐酸一水合物)的浓度计算CFI或DRCFI给药后的肺剂量[3]。 |
| Data Literature Source | [1]. Peltzer PM，et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7. [2]. Steenbergen J，et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21. [3]. Hamblin KA，et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91 |
| Unit | Piece |
| Specification | 50mg 10mM*1mL in Water 100mg 200mg |
Ciprofloxacin hydrochloride 是一种抗生素，具有高效的抗菌活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Paper-based antibiotic sensor (PAS) relying on colorimetric indirect competitive enzyme-linked immunosorbent assay for quantitative tetracycline and chloramphenicol detection
Click to check >>Author：Wang X .Li J .Jian D
IF：7.2900
Publish_to：Sensors and Actuators B Chemica
PMID：
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