{{cart_num}}
My CartCAS：514-10-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 514-10-3 |
| Name | Abietic Acid |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.45 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-178-3 |
| MDL | MFCD03423567 |
| SMILES | C[C@@]1(C2[C@@](CCC1)(C)[C@@]3([H])CCC(C(C)C)=CC3=CC2)C(O)=O |
| InChIKey | RSWGJHLUYNHPMX-ONCXSQPRSA-N |
| InChI | InChI=1S/C20H30O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h7,12-13,16-17H,5-6,8-11H2,1-4H3,(H,21,22)/t16-,17+,19+,20+/m0/s1 |
| PubChem CID | 10569 |
| Target Point | 5-lipoxygenase;5-LOX |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a tricyclic diterpenoid oxygen-containing compound, which can inhibit lipoxygenase activity. |
| Biological Activity | Abietic acid (Sylvic acid，Abietate，Rosin Acid)，an abietane diterpenoid，inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.[1-2] |
| In Vitro | Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis[2]. Abietic acid is a PPARγ ligand and that its anti-in￡ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide(LPS)-stimulated macrophages，abietic acid suppresses production of prostaglandin E2(PGE2)in vitro and in vivo[1]. |
| In Vivo | Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis[2]. |
| Cell Experiment | Animal Models: Male C57BL/6J mice; Dosages: 20 mg/kg and 40 mg/kg; Administration: oral administration[2] |
| Animal Experiment | pM-hPPARγ，p4xUASg-tk-luc，pCMX-CBP and pRL-CMV are transfected into CV1 cells and then，24 h after the transfection，the cells are treated with abietic acid at various concentrations for 24 h.[3] |
| Data Literature Source | [1] Ulusu NN，et al. Phytother Res. 2002，16(1):88-90. [2] Hwang KH，et al. J Med Food. 2011，14(9):1052-6. [3] Takahashi N，et al. FEBS Lett. 2003，550(1-3):190-4. |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
