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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > SchaftosideCAS：51938-32-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 51938-32-0 |
| Name | Schaftoside |
| Molecular Formula | C26H28O14 |
| Molecular Weight | 564.49 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | OC1=C([C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C(O)=C3C(OC(C4=CC=C(O)C=C4)=CC3=O)=C1[C@H](OC[C@H](O)[C@@H]5O)[C@@H]5O |
| Target Point | Toll-like Receptor (TLR) |
| Passage | Immunology & Inflammation |
| Background | Schaftoside is a flavonoid found in a variety of Chinese herbal medicines. Schaftoside inhibits TLR4 and Myd88 expression. |
| Biological Activity | Schaftoside 是在多种中草药（如 Eleusine indica）中发现的黄酮类化合物。Schaftoside 抑制 TLR4 和 Myd88 表达。 Schaftoside 还降低 Drp1 表达和磷酸化，并减少线粒体分裂。[1] |
| In Vitro | Schaftoside抑制三种促炎酶活性：分泌型磷脂酶A2(sPLA2)，脂氧合酶(LOX)和环氧合酶2(COX-2)。 Schaftoside还抑制促炎细胞因子(IL-1β，TNF-α和IL-6)的mRNA和蛋白表达[1]。 |
| Data Literature Source | [1]. Zhou K，et al. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. J Pharmacol Sci. 2019 Jan;139(1):15-22. |
| Unit | Piece |
| Specification | 5mg 10mg 20mg |
Schaftoside 是在多种中草药中发现的黄酮类化合物。Schaftoside 抑制 TLR4 和 Myd88 表达。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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