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My CartCAS：501-94-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 501-94-0 |
| Name | Tyrosol |
| Molecular Formula | C8H10O2 |
| Molecular Weight | 138.16 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-930-8 |
| MDL | MFCD00002902 |
| SMILES | OCCC1=CC=C(O)C=C1 |
| InChIKey | YCCILVSKPBXVIP-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H2 |
| PubChem CID | 10393 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | Tyrosol is a derivative of phenyl ethanol, which can reduce the pro-inflammatory cytokines from astrocytes and reduce the activation of NF-κB. Tyrosol has antioxidant and anti-inflammatory effects. |
| Biological Activity | Tyrosol 是苯乙醇的衍生物。Tyrosol 减弱来自星形胶质细胞的促炎细胞因子，且降低 NF-κB 活化。具有抗氧化和抗炎作用[1-2]。 |
| In Vitro | 酪醇(1.6 mM)显著增加暴露于氧葡萄糖剥夺(OGD)的培养星形胶质细胞的细胞活力[1]。酪醇(1.6 mM)通过调节Janus N末端激酶(JNK)减弱星形胶质细胞释放的TNF-α和IL-6水平[1]。由于酪氨酸(1.6mM)减弱GFAP(胶质原纤维酸性蛋白)的表达水平和STAT3的磷酸化[1]，因此星形胶质细胞的细胞因子减少可能是由于其抑制星形胶质细胞活化和调节STAT3信号通路。酪醇可以防止OGD暴露的星形胶质细胞中IκBα的降解和IκBα磷酸化的增加，从而导致缺血期间NF-κB功能的抑制[1]。 |
| In Vivo | 足底注射角叉菜胶导致爪厚度显著增加，在注射后2小时达到峰值。当在用角叉菜胶处理之前注射酪醇(0.5mg/kg)或酪醇硫酸盐时，这种效果降低。在以0.5mg/kg的剂量施用酪醇并且以0.1mg/kg的剂量施用酪醇 - 硫酸盐之后获得类似的爪水肿的AUC值。 |
| Data Literature Source | [1]. Luo G，et al. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation. Neurochem Int. 2018 Dec;121:140-145. [2]. Muriana FJG，et al. Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells. Food Funct. 2017 Aug 1;8(8):2905-2914. |
| Unit | Bottle |
| Specification | 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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