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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Sinapine thiocyanateCAS：7431-77-8
Molecular Formula：C16H24NO5·CNS
Molecular Weight：368.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 7431-77-8 |
| Name | Sinapine thiocyanate |
| Molecular Formula | C16H24NO5·CNS |
| Molecular Weight | 368.45 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13195301 |
| SMILES | COC1=C(O)C(OC)=CC(C=CC(OCC[N+](C)(C)C)=O)=C1.N#C[S-] |
| Target Point | P-gp(P-glycoprotein) |
| Passage | Membrane Transporter&Ion Channel |
| Background | Sinapine is an alkaloid with activities such as antioxidant and radioprotective. |
| Biological Activity | Sinapine是来自十字花科物种的生物碱，具有抗氧化剂和放射性保护等活性。[1-3] |
| In Vitro | 芥子碱以剂量依赖性方式增加Caco-2细胞对阿霉素的敏感性，而在仅用阿霉素处理的细胞中观察到没有或更少的效果。芥子碱和阿霉素的组合具有协同作用并增加多柔比星对Caco-2细胞的细胞毒性。结果表明，芥子碱通过抑制FGFR4-FRS2a-ERK1/2信号通路在下调P-糖蛋白表达中起重要作用[1]。芥子碱可以有效地保护免受OH诱导的DNA和MSCs损伤，从而可能在MSCs移植中具有治疗潜力[2]。 |
| In Vivo | 在前8天，通过摄入芥子碱和其他酚类化合物，大鼠的干物质摄入量和活体重增加显著降低。然而，在这个适应期后，他们的表现与对照组相似[3]。 |
| Cell Experiment | 将Caco-2细胞以8000个细胞/孔接种到96孔板中24小时。在用不同剂量的芥子碱(0-200μM)，多柔比星或两者孵育24小时后，弃去培养基。通过MTT比色测定法检测单独暴露于芥子碱或芥子碱与抗肿瘤剂多柔比星的组合后的细胞存活[1]。 |
| Animal Experiment | 大鼠[3]将60只雄性Sprague-Dawley大鼠(95g)随机分配到6组，每组10只大鼠，并在各个笼子中饲养。六组10只生长的大鼠各自随意喂养15天，六种饮食中的一种：饮食A，油菜籽(3.80g芥子碱/ kg DM);饮食B，乙醇/水提取的油菜籽(0.48g芥子碱);饮食C，控制饮食;饮食G，控制饮食+ 3.74克提取的芥子碱;饮食H，控制饮食+ 3.72克芥子碱+其他酚类化合物;或饮食I，控制饮食+芥子碱和其他酚类化合物的水解产物。在试验的第1，4，8，11和15天，将大鼠在上午8点称重。在处死后，消除肠内容物以允许确定空体重增加(EBWG)。每天记录每只大鼠的分布，拒绝和摄入[3]。 |
| Data Literature Source | [1]. Guo Y，et al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. [2]. Li X，et al. Protective Effect of Sinapine against Hydroxyl Radical-Induced Damage to Mesenchymal Stem Cells and Possible Mechanisms. Chem Pharm Bull (Tokyo). 2016;64(4):319-25. [3]. Vermorel M，et al. Valorization of rapeseed meal. 5. Effects of sinapine and other phenolic compounds on food intake and nutrient utilization in growing rats. Reprod Nutr Dev. 1987;27(4):781-90. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Sinapine是一种生物碱，具有抗氧化剂和放射性保护等活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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