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My CartCAS：115841-09-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 115841-09-3 |
| Name | Salvianolic acid C |
| Molecular Formula | C26H20O10 |
| Molecular Weight | 492.43 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16660675 |
| SMILES | OC1=C(O)C=CC(C[C@H](C(O)=O)OC(/C=C/C2=CC=C(O)C3=C2C=C(C4=CC(O)=C(O)C=C4)O3)=O)=C1 |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | Salvianolic acid C is a non-competitive inhibitor of cytochrome P4502C8 (CYP2C8) and a mixed inhibitor of cytochrome P4502J2 (CYP2J2). |
| Biological Activity | Salvianolic acid C 是细胞色素 P4502C8 (CYP2C8) 的非竞争性抑制剂和细胞色素 P4502J2 (CYP2J2) 中等强度的混合抑制剂，其对 CYP2C8 和 CYP2J2 的 Ki 值分别为 4.82 μM 和 5.75 μM。[1-2] |
| In Vitro | 1和5μM丹酚酸C(SalC)可显著抑制LPS诱导的NO产生。丹酚酸C显著降低iNOS的表达。丹酚酸C抑制LPS诱导的TNF-α，IL-1β，IL-6和IL-10过量产生。丹酚酸C抑制LPS诱导的NF-κB活化。丹酚酸C还增加BV2小胶质细胞中Nrf2和HO-1的表达[2]。 |
| In Vivo | 丹酚酸C(20mg/kg)治疗可显著降低逃避潜伏期。此外，与LPS模型组相比，SalC(10和20mg/kg)治疗显著增加平台穿越数。与模型组相比，丹酚酸C的全身给药下调脑TNF-α，IL-1β和IL-6水平。大鼠大脑皮层和海马中的iNOS和COX-2水平高于对照组，而丹酚酸C处理显著下调皮质和海马区域。丹酚酸C(5，10和20 mg/kg)治疗剂量依赖性地增加大鼠大脑皮层和海马中的p-AMPK，Nrf2，HO-1和NQO1水平[2]。 |
| Data Literature Source | [1]. Xu MJ，et al. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chem Biol Interact. 2018 Jun 1;289:15-22. [2]. Song J，et al. Activation of Nrf2 signaling by salvianolic acid C attenuates NF κB mediated inflammatory response both in vivo and in vitro. Int Immunopharmacol. 2018 Oct;63:299-310. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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