{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Saikosaponin CCAS：20736-08-7
Molecular Formula：C48H78O17
Molecular Weight：927.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 20736-08-7 |
| Name | Saikosaponin C |
| Molecular Formula | C48H78O17 |
| Molecular Weight | 927.14 |
| Solubility | Soluble in DMSO ≥100mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00075673 |
| SMILES | O[C@H]([C@@H](O)[C@]([H])(O[C@@H]1C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])C=C[C@@]45[C@@]2(C)C[C@H](O)[C@]6(CO5)[C@@]4([H])CC(C)(C)CC6)([H])[C@]3(C)CC1)O[C@@H]7CO[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H]7O[C@]9([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O |
| Target Point | tau protein;Amyloid-β |
| Passage | Cytoskeleton;Neuronal Signaling |
| Background | Saikosaponin C is the active ingredient in bupleurum, mainly acting on amyloid beta and tau proteins in Alzheimers disease. Saikosaponin C inhibits the release of Aβ1-40 and Aβ1-42 and the phosphorylation of abnormal tau proteins. |
| Biological Activity | saikosaponin C (SSc), one of the main bioactive components produced by the traditional Chinese herb, radix bupleuri, the root of Bupleurum falcatum, against AD in various neuronal models. SSc has dual effects on AD by targeting amyloid beta (Aβ) and tau, two key proteins in AD. [1]. |
| In Vitro | SSc also inhibited abnormal tau phosphorylation at multiple AD-related residues. Moreover，SSc seems to have beneficial effects on cellular tau function; it accelerated nerve growth factor-mediated neurite outgrowth and increased the assembly of microtubules. In addition，SSc increased synaptic marker proteins such as synaptophysin and PSD-95. Saikosaponin C，an active component of Bupleuri Radix，inhibits abnormal tau phosphorylation and amyloid beta production，thereby promoting synaptic integrity. Saikosaponin C also prevents amyloid beta-induced apoptosis in brain vascular endothelial cells. Therefore，Saikosaponin C may provide a new therapeutic strategy for treatment of neurodegenerative diseases，including Alzheimer's disease.[1] |
| Animal Experiment | SSc significantly suppressed the release of both Aβ peptides 1-40 and 1-42 into cell culture supernatants[1]. |
| Data Literature Source | [1]. Lee TH1，et al. A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent. J Neurochem. 2016 Mar;136(6):1232-1245. |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO 20mg |
aikosaponin C 是柴胡中的活性成分，在阿尔滋海默症中主要作用于 amyloid beta 和 tau 蛋白。Saikosaponin C 抑制 Aβ1-40 和 Aβ1-42 的释放，抑制异常 tau 蛋白的磷酸化。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
