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My CartCAS：472-11-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 472-11-7 |
| Name | Ruscogenin |
| Molecular Formula | C27H42O4 |
| Molecular Weight | 430.62 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-447-2 |
| MDL | MFCD00210550 |
| SMILES | C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2 |
| Target Point | NLRP3 |
| Passage | Immunology & Inflammation |
| Background | Ruscogenin is an important steroidal sapogenin |
| Biological Activity | Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1-2]. |
| In Vitro | Ruscogenin(0.1-10 μM)treatment increased cell viability and transendothelial electrical resistance(TEER)value，decreased sodium fluorescein leakage，and modulated the TJs expression in OGD/R-induced bEnd.3 cells. Moreover，ruscogenin also inhibited the expression of interleukin-1β(IL-1β)and caspase-1，and markedly suppressed the expression of Nucleotide-binding domain(NOD)-like receptor family，pyrin domain containing 3(NLRP3)and thiredoxin interactive protein(TXNIP)in vivo and in vitro. Furthermore，ruscogenin decreased reactive oxygen species(ROS)generation and inhibited the mitogen-activated protein kinase(MAPK)pathway in OGD/R-induced bEnd.3 cells. [1] |
| In Vivo | The results demonstrated that administration of ruscogenin(10 mg/kg)decreased the brain infarction and edema，improved neurological deficits，increased cerebral brain flow(CBF)，ameliorated histopathological damage，reduced evans blue(EB)leakage and upregulated the expression of tight junctions(TJs)in MCAO/R-injured mice. [1] |
| Data Literature Source | [1]. Cao G，et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. [2]. Huang YL，et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Ruscogenin 是一种重要甾体皂苷元
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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