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My CartCAS：537-42-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 537-42-8 |
| Name | Pterostilbene |
| Molecular Formula | C16H16O3 |
| Molecular Weight | 256.3 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 611-041-4 |
| MDL | MFCD00238710 |
| SMILES | OC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1 |
| Target Point | ROS |
| Passage | Immunology & Inflammation |
| Background | Pterostilbene has various physiological activities such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetic and anti-obesity. |
| Biological Activity | Pterostilbene 是从蓝莓和囊状紫檀中得到的芪类化合物[1]，具有抗氧化、抗炎、抗癌、抗糖尿病和抗肥胖等功效[1][4]。Pterostilbene 抑制 ROS 的生成[3]，能对抗多种自由基，例如 DPPH，ABTS，hydroxyl，superoxide 和 hydrogen peroxide 等[4]。 |
| In Vitro | 紫檀芪(0，5，25，50，100，200和400μM)显示出对HeLa细胞生长的抑制活性，在24和48小时时IC50分别为101.2μM和65.9μM。 Ipterostilbene(0，25，100和200μM)也诱导HeLa细胞凋亡[2]。紫檀芪(0.05，0.1，0.15和0.2mM)以剂量依赖性方式对DPPH，ABTS，羟基，超氧化物，过氧化氢具有高抗氧化活性。紫檀芪降低脂质过氧化物和氢过氧化物，减少蛋白质羰基并恢复蛋白质巯基以响应TBHP和As-Fe2 +的损害。紫檀芪还抑制pBR322中的单链断裂[4]。 |
| In Vivo | 紫檀芪(30 mg / kg每日，po为21天)抑制炎症动物模型中活性氧的产生[3]。 |
| Data Literature Source | [1]. McCormack D， et al. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013; 2013:575482. [2]. Hong Bin W， et al. Pterostilbene (3'，5'-dimethoxy-resveratrol) exerts potent antitumor effects in HeLa human cervical cancer cells via disruption of mitochondrial membrane potential， apoptosis induction and targeting m-TOR/PI3K/Akt signalling pathway. J BUON. 2018 Sep-Oct; 23 (5) :1384-1389. [3]. Perecko T， et al. The effects of pterostilbene on neutrophil activity in experimental model of arthritis. Biomed Res Int. 2013; 2013:106041. [4]. Acharya JD， et al. Protective effect of Pterostilbene against free radical mediated oxidative damage. BMC Complement Altern Med. 2013 Sep 26; 13:238. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Examples of using this product（for reference only）
In Vivo:
Mice（ 10,~40 mg/kg Pte;I.P）:
All mice are randomly divided into six groups as the following: (1) control group; (2) LPS/D-Gal group (LPS 50μg/kg and D-Gal 500 mg/kg); (3–5) LPS/D-Gal + Pte (10,20, and 40 mg/kg) groups; and (6) Pte (40 mg/kg) only group. Prior to the LPS/D-Gal challenge, Pte (10, 20, and 40 mg/kg) is injected intraperitoneally twice in groups 3 to 6 (12 h apart). One hour after the last pretreatment of Pte, mice in 2–5 groups are treated intraperitoneally with LPS (50 μg/kg) and D-Gal (500 mg/kg) to establish ALI models. All animals are sacrificed 9 h after LPS/D-Gal treatment to obtain blood samples and liver tissues.
Reference：
Liu Z, Wang J, Zhang Y, Wu D, Li S, Jiang A, Du C, Xie G. Pterostilbene Exerts Hepatoprotective Effects through Ameliorating LPS/D-Gal-Induced Acute Liver Injury in Mice. Inflammation. 2021 Apr;44(2):526-535. doi: 10.1007/s10753-020-01349-z. Epub 2020 Oct 2. PMID: 33006074.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Liu Z,et al. Inflammation. 2021 Apr;44(2):526-535.
Liu Z,et al. Inflammation. 2021 Apr;44(2):526-535.
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