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My CartCAS：501-97-3
Molecular Formula：C9H10O3
Molecular Weight：166.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 501-97-3 |
| Name | Phloretic acid |
| Molecular Formula | C9H10O3 |
| Molecular Weight | 166.17 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-931-3 |
| MDL | MFCD00002778 |
| SMILES | C1=C(C=CC(=C1)O)CCC(O)=O |
| InChIKey | NMHMNPHRMNGLLB-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H10O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5,10H,3,6H2,(H,11,12) |
| PubChem CID | 10394 |
| Target Point | Influenza Virus |
| Passage | Anti-infection |
| Background | Desaminotyrosine is a microbe-associated metabolite that prevents influenza by amplifying type I interferon signaling. |
| Biological Activity | Desaminotyrosine 是一种微生物相关的代谢物，通过扩大 I 型干扰素 (type I interferon) 信号来阻止 influenza 的发生。[1] |
| In Vivo | 野生型小鼠每克粪便产生纳摩尔的Desaminotyrosine，血清中含有皮摩尔量的Desaminotyrosine。在流感感染之前的脱氨基酪氨酸(200mM)治疗通过I型干扰素(IFN)信号传导来预防流感，对于具有或不具有万古霉素，新霉素，氨苄青霉素和甲硝唑(VNAM)的小鼠的体重减轻或存活没有影响。 Desaminotyrosine通过小鼠中的I型IFN扩增增强巨噬细胞中的I型IFN [1]。 |
| Animal Experiment | 小鼠[1]指示的小鼠在饮用水中接受溶解在Kool-Aid中的200mM脱氨基酪氨酸(对照动物单独接受Kool-Aid)。指示小鼠接受万古霉素，新霉素，氨苄青霉素和甲硝唑(VNAM)治疗小鼠1mg/kg的聚(IC)注射，或每天腹膜内注射所有其他小鼠5mg/kg，持续4天，然后小鼠在第5天被瘢痕化此时收集血清[1]。 |
| Data Literature Source | [1]. Steed AL，et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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