{{cart_num}}
My CartCAS：18916-17-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 18916-17-1 |
| Name | Naringin dihydrochalcone |
| Molecular Formula | C27H34O14 |
| Molecular Weight | 582.55 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08436145 |
| SMILES | O=C(C1=C(O)C=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O[C@@]3([H])[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)C=C1O)CCC4=CC=C(O)C=C4 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | Naringin Dihydrochalcone is a sweetener derived from naringin. |
| Biological Activity | 柚皮素表现出抗氧化，抗炎和抗细胞凋亡等生物活性。Naringin 可抑制 NF-κB 信号通路。[1-4] |
| In Vitro | 柚皮苷抑制NF-κB信号通路激活。柚皮素抑制HBZY-1细胞中高葡萄糖诱导的增殖，炎症反应和氧化应激损伤[1]。柚皮苷以剂量和时间依赖性方式抑制AGS癌细胞增殖。在Naringin处理的AGS细胞中，PI3K及其活化的下游靶标p-Akt和p-mTOR的磷酸化在2mM处显着降低。柚皮苷在AGS细胞中诱导自噬细胞死亡。柚皮苷激活AGS细胞中的自噬相关蛋白[2]。柚皮苷保护PC12细胞免受3-NP神经毒性。在3-NP诱导的PC12细胞中柚皮苷处理后乳酸脱氢酶释放减少。柚皮苷处理通过增加酶抗氧化剂的活性和还原型谷胱甘肽的水平来增强抗氧化防御[3]。 |
| In Vivo | 柚皮苷治疗显着减轻糖尿病大鼠肾损伤，显着增加糖尿病大鼠体重。柚皮苷的给药有效地减轻了糖尿病大鼠的胶原沉积和肾间质纤维化。柚皮苷治疗可导致ROS和MDA水平降低，SOD和GSH-Px活性增加[1]。柚皮苷的口服给药显着提高了学习和记忆能力。柚皮苷显着增强胰岛素信号通路[3]。 |
| Cell Experiment | 将HBZY-1细胞接种到96孔板中，并用各种浓度(1，5，10，25，50，100μM)的柚皮苷预处理2小时。然后用30mM葡萄糖处理细胞24小时。对照组加入相同体积的无菌生理盐水。处理后，将所有孔与20μl5mg/ ml MTT在37℃温育4小时。随后，在去除上清液后，使用100μlDMSO溶解形成的甲crystals晶体。结果在酶标仪上以490nm记录[1]。 |
| Animal Experiment | 大鼠：将大鼠随机分为6组：对照组，柚皮苷(80 mg / kg)，STZ，STZ +柚皮苷(20 mg / kg)，STZ +柚皮苷(40 mg / kg)，STZ +柚皮苷(80 mg /公斤)。 STZ和STZ +柚皮苷组大鼠腹腔注射STZ(65mg / kg)。对照组和柚皮苷组腹膜内注射相同体积的0.1M柠檬酸盐缓冲液。注射STZ 3天和5天后，通过尾静脉穿刺血液采样测量血糖水平[1]。小鼠：将60只4周龄雄性小鼠随机分成4组，用对照饮食或高脂饮食饲料喂养20周。每天给小鼠服用100mg / kg的柚皮苷。每周测量小鼠体重和食物摄入量。在行为评估之后，用异氟烷深度麻醉动物并在禁食至少5小时后通过断头处死。收集他们的血浆用于进一步分析[4]。 |
| Data Literature Source | [1]. Chen F， et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30; 10 (11) :e0143868. [2]. Raha S， et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep; 47 (3) :1061-9. [3]. Kulasekaran G， et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov; 409 (1-2) :199-211. [4]. Wang D， et al. Naringin Improves Neuronal Insulin Signaling， Brain Mitochondrial Function， and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct; 35 (7) :1061-71 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg |
Naringin Dihydrochalcone是由柚皮苷衍生的甜味剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
