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My CartCAS：260413-62-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 260413-62-5 |
| Name | Ligustroflavone |
| Molecular Formula | C33H40O18 |
| Molecular Weight | 724.67 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22125004 |
| SMILES | O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO[C@H](O[C@@H](C)[C@H](O)[C@H]3O)[C@@H]3O)[C@@H](O)[C@@H]4O)[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)=C6)C2=C6O |
| Target Point | CaSR (calcium-sensing receptor) |
| Passage | GPCR & G Protein |
| Background | Ligastroflavone is a potential calcium-sensing receptor (CaSR) antagonist. |
| Biological Activity | Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR).Ligustroflavone could transiently increase PTH level and regulate calcium metabolism as well as prevent osteoporosis in diabetic mice, suggesting that ligustroflavone might be an effective antagonist on CaSR.[1] |
| In Vitro | LF interacted well with the allosteric site of CaSR shown by molecular docking analysis，increased PTH release of primary parathyroid gland cells and suppressed extracellular calcium influx in HEK-293 cells. [1] |
| In Vivo | The serum level of PTH attained peak value at 2 h and maintained high during the period of 1 h and 3 h than that before treatment in mice after a single dose of LF. Treatment of diabetic mice with LF inhibited the decrease in calcium level of serum and bone and the enhancement in urinary calcium excretion as well as elevated circulating PTH levels. Trabecular bone mineral density and micro-architecture were markedly improved in diabetic mice upon to LF treatment for 8 weeks. LF reduced CaSR mRNA and protein expression in the kidneys of diabetic mice. [1] |
| Data Literature Source | [1]. Feng R，et al. Protective Effects of Ligustroflavone，an Active Compound from Ligustrum lucidum，on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist. Am J Chin Med. 2019;47(2):457-476. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Ligustroflavone 是一种潜在的钙敏感受体(CaSR) 拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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