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My CartCAS：657-27-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 657-27-2 |
| Name | L-Lysine monohydrocholoride |
| Molecular Formula | C6H14N2O2·HCl |
| Molecular Weight | 182.65 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 211-519-9 |
| MDL | MFCD00064564 |
| SMILES | N[C@@H](CCCCN)C(O)=O.[H]Cl |
| Target Point | Others |
| Passage | Others |
| Background | L-lysine hydrochloride is an essential amino acid for humans. |
| Biological Activity | L-lysine hydrochloride人类必需的氨基酸，具有多种益处，包括治疗疱疹，增加钙吸收，减少糖尿病相关疾病和改善肠道健康。[1-3] |
| In Vivo | L-赖氨酸处理通过抑制炎性细胞因子IL-6的释放并增强抗氧化活性来减弱由L-精氨酸诱导的胰腺组织损伤。用L-赖氨酸处理前或后处理导致丙二醛和一氧化氮水平显著降低，而在抗氧化酶(超氧化物歧化酶，过氧化氢酶和谷胱甘肽过氧化物酶)和谷胱甘肽的活性中观察到显著增强[1]。补充L-赖氨酸几乎完全改善血管钙化。膳食L-赖氨酸强烈抑制腺嘌呤大鼠血浆完整的甲状旁腺激素，并支持适当的骨血管轴。 Lys组中股骨磷灰石的保守取向也证明了L-赖氨酸的骨保护作用。膳食L-赖氨酸升高血浆丙氨酸，脯氨酸，精氨酸和高精氨酸但不升高赖氨酸[2]。在人体中观察到在大鼠中观察到的胃排空的剂量依赖性延迟，其中胃排空4分钟/ g L-赖氨酸的半衰期增加。此外，观察到肠液积累的剂量依赖性增加(0.4mL/min/g L-赖氨酸)[3]。 |
| Animal Experiment | 大鼠：通过渗透微型泵以40μg/ kg /天的剂量连续注射大鼠PTH 1-34诱导6周龄雄性Wistar大鼠的肾钙质沉着50小时。在植入渗透泵后2小时，14小时，26小时和38小时，通过胃管给予剂量为20mmol/kg的L-赖氨酸HCl或甘氨酸。在指定的时期，血清和尿液生化参数，尿素氮，白蛋白，钙，无机磷酸盐和镁由临床诊断试剂确定[2]。小鼠：评估四组小鼠(每组10只)。第一组是控制。给组II-IV中的动物腹膜内注射L-精氨酸盐酸盐(400mg/kg体重[bw])3天。 III组动物用L-赖氨酸(10mg/kg体重)口服预处理，而IV组动物用L-赖氨酸(10mg/kg体重)口服后处理。对血清样品进行淀粉酶，脂肪酶，转氨酶和白细胞介素-6(IL-6)测定。切除胰腺以测量丙二醛，一氧化氮，过氧化氢酶，超氧化物歧化酶，还原型谷胱甘肽和谷胱甘肽过氧化物酶的水平[1]。 |
| Data Literature Source | [1]. Al-Malki AL，et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [2]. Shimomura A，et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [3]. Baruffol C，et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009 |
| Unit | Bottle |
| Specification | 500mg 1g |
L-lysine hydrochloride人类必需的氨基酸。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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