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My CartCAS：61-90-5
Molecular Formula：C6H13NO2
Molecular Weight：131.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 61-90-5 |
| Name | L-Leucine |
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.17 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-522-0 |
| MDL | MFCD00002617 |
| SMILES | N[C@@H](CC(C)C)C(O)=O |
| InChIKey | ROHFNLRQFUQHCH-YFKPBYRVSA-N |
| InChI | InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 |
| PubChem CID | 6106 |
| Target Point | Others |
| Passage | Others |
| Background | L-Leucine is an essential branched-chain amino acid (BCAA) that activates the mTOR signaling pathway. |
| Biological Activity | L-Leucine 是一种必需的支链氨基酸 (BCAA)，可激活 mTOR 信号通路[1]。 |
| In Vitro | 在E13.5大鼠胰腺外植体中，在没有添加L-亮氨酸的情况下，培养1天后Ngn3 mRNA水平增加，在第3天达到峰值，然后降低。当加入L-亮氨酸时，在Ngn3 mRNA水平中观察到显著降低。 Ngn3 mRNA水平的降低与Ngn3表达细胞数量的减少相平行(4728±408对959±28; P <0.01)。最后，L-亮氨酸还对三种基因的mRNA水平产生剂量依赖性抑制作用，即Ngn3，其靶标Insm1和胰岛素[1]。亮氨酸通过增强mTORC1活化刺激新生猪骨骼肌中的蛋白质合成。 L-亮氨酸增加细胞内HIF-1α水平并激活HIF-1α信号传导途径，并且这两种作用由mTOR信号传导途径介导。该过程导致Ngn3抑制，并因此降低β细胞分化[1]。 |
| Data Literature Source | [1]. Rachdi L，et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17 |
| Unit | Bottle |
| Specification | 200mg 10mM*1mL in Water 500mg 1g |
L-Leucine 是一种必需的支链氨基酸 (BCAA)，可激活 mTOR 信号通路。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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