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My CartCAS：156-38-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：GC≥99%
Appearance：White to yellow Solid
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| CAS | 156-38-7 |
| Name | 4-Hydroxyphenylacetic acid |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.15 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | GC≥99% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-851-3 |
| MDL | MFCD00004347 |
| SMILES | O=C(O)CC1=CC=C(O)C=C1 |
| InChIKey | XQXPVVBIMDBYFF-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11) |
| PubChem CID | 127 |
| Target Point | Keap1-Nrf2 |
| Passage | NF-κB |
| Background | 4-Hydroxyphenylacetic acid is a major microbiota-derived polyphenol metabolite with antioxidant activity. |
| Biological Activity | 4-Hydroxyphenylacetic acid 是一种主要的微生物群衍生的多酚代谢物，具有抗氧化作用。4-hydroxyphenylacetic acid 诱导 Nrf2 表达[1]。 |
| In Vivo | 4-羟基苯乙酸(6，12或25 mg/kg)可增加Nrf2向细胞核的转位，并增强II期和抗氧化酶的活性。与对照组相比，预处理12和25 mg/kg 4-羟基苯乙酸组的核Nrf2蛋白水平分别增加了170％和230％。最终剂量为25的4-羟基苯乙酸预处理mg/kg显著且选择性地上调II期酶的靶基因，并导致比对照组更高的上调270％，400％和500％或UGT1A1，UGT1A9和SULT2A1。 4-羟基苯乙酸也抑制CYP2E1的表达[1]。 |
| Data Literature Source | [1]. Zhao H，et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
4-Hydroxyphenylacetic acid 是一种主要的微生物群衍生的多酚代谢物，具有抗氧化活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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