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Guaiacol

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Cat.No：IG0880 Solarbio

CAS：1990/5/1

Molecular Formula：C₇H₈O₂

Molecular Weight：124.14

Storage：Store at 2-8℃，2 years

Purity：HPLC≥98%

Appearance：Colorless to light yellow ＜26℃ Solid，＞29℃ Liquid

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Product Information

CAS	1990/5/1
Name	Guaiacol
Molecular Formula	C₇H₈O₂
Molecular Weight	124.14
Solubility	Soluble in Water/DMSO
Purity	HPLC≥98%
Appearance	Colorless to light yellow ＜26℃ Solid，＞29℃ Liquid
Storage	Store at 2-8℃，2 years
EC	EINECS 201-964-7
MDL	MFCD00002185
SMILES	OC1=CC=CC=C1OC
InChIKey	LHGVFZTZFXWLCP-UHFFFAOYSA-N
InChI	InChI=1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
PubChem CID	460
Target Point	COX
Passage	Immunology & Inflammation
Background	Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation.
Biological Activity	Guaiacol 是一种从愈创木树脂分离的酚类化合物，抑制 LPS 刺激的 COX-2 表达和 NF-κB 激活[1]。具有抗炎活性[1]。
In Vitro	愈创木酚抑制LPS刺激的核因子κB(NF-κB)活化和环氧合酶(COX)-2基因在RAW 264.7鼠巨噬细胞系细胞中的表达。苯酚，丁香酚，愈创木酚和香兰素等酚类化合物抑制绵羊囊泡腺前列腺素环加氧酶，其浓度为50％，按以下顺序递减：苯酚(1600μM)>香草醛(>500μM)>愈创木酚(72)μM)>丁香酚(12μM)[1]。
Data Literature Source	[1]. Murakami Y， et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr; 27 (2) :801-7.
Unit	Bottle
Specification	20mg

Guaiacol 是一种酚类化合物，抑制 LPS 刺激的 COX-2 表达和 NF-κB 激活。

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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