Glabridin
Cat.No:IG0680 Solarbio
CAS:59870-68-7
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:HPLC≥98%
Appearance:Off-white to yellow Solid
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GlabridinCAS:59870-68-7
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:HPLC≥98%
Appearance:Off-white to yellow Solid
Qty:
Size:
CAS | 59870-68-7 |
Name | Glabridin |
Molecular Formula | C20H20O4 |
Molecular Weight | 324.37 |
Solubility | Soluble in DMSO |
Purity | HPLC≥98% |
Appearance | Off-white to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 611-908-7 |
MDL | MFCD03427694 |
SMILES | OC1=CC=C([C@H]2CC3=CC=C4C(C=CC(C)(C)O4)=C3OC2)C(O)=C1 |
Target Point | PPAR agonist |
Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
Background | Glabridin binds and activates PPARγ. |
Biological Activity | Glabridin 能够结合并激活 PPARγ,EC50 值为 6115 nM。Glabridin 具有抗氧化、抗菌、抗肾炎、抗糖尿病、抗肿瘤、抗炎、抗骨质疏松、保护心血管、保护神经、清除自由基等作用[1-3]。 |
IC50 | PPARγ:6.1μM(EC50) |
In Vitro | Glabridin结合并激活PPARγ,EC50为6115 nM [1]。 Glabridin(40,80μM)在治疗24和48小时后以剂量和时间依赖性方式抑制SCC-9和SAS细胞系的增殖[2]。 Glabridin(0-80μM)也诱导细胞凋亡,导致SCC-9和SAS细胞系中的亚G1期细胞周期停滞[2]。 Glabridin(0,20,40和80μM)剂量依赖性地激活caspase-3,-8和-9并增加PARP裂解,显著磷酸化SCC-9中的ERK1/2,JNK1/2和p-38 MAPK。细胞[2]。 |
In Vivo | Glabridin(50 mg/kg,po每日一次)显示出强效的抗炎活性,改善了葡聚糖硫酸钠(DSS)诱导的大鼠炎症改变[3]。 |
Data Literature Source | [1]. Rebhun JF,et al. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ). Fitoterapia. 2015 Oct;106:55-61. [2]. Chen CT,et al. Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway. Environ Toxicol. 2018 Jun;33(6):679-685. [3]. El-Ashmawy NE,et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26(2):551-559. |
Unit | Bottle |
Specification | 10mg 10mM*1mL in DMSO 20mg |
Glabridin 能够结合并激活 PPARγ。
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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