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My CartCAS：60976-49-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 60976-49-0 |
| Name | Geraniin |
| Molecular Formula | C41H28O27 |
| Molecular Weight | 952.65 |
| Solubility | Soluble in DMSO ≥100mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09038731 |
| SMILES | O=C(OC[C@H](O[C@@H](OC(C1=CC(O)=C(O)C(O)=C1)=O)[C@H]2OC3=O)[C@H](OC(C(C4C5=C3C=C(O)C(O)=C5OC6(O)C4(O)O)=CC6=O)=O)[C@H]2O7)C8=CC(O)=C(O)C(O)=C8C9=C(O)C(O)=C(O)C=C9C7=O |
| Target Point | TNF Receptor |
| Passage | Apoptosis |
| Background | Geraniin is a tumor necrosis factor alpha (TNF-alpha) release inhibitor. It has anti-tumor, anti-inflammatory and anti-hyperglycemic activity. |
| Biological Activity | Geraniin 是具有抗肿瘤、抗炎、抗高血糖活性的、肿瘤坏死因子α (TNF-α) 的释放抑制剂，其 IC50 值为 43 μM。[1-2] |
| IC50 | 43μM(TNF-α)[1]. |
| In Vitro | 对于Geraniin，TNF-α释放抑制的IC50值为43μM[1]。香叶素长期以来被用作药草，并具有许多活性，包括抗癌，抗炎和抗高血糖活性。 Geraniin以浓度依赖性方式显著降低OVCAR3和SKOV3细胞的活力。在OVCAR3细胞中，Geraniin处理的IC50值为34.5±2.8μM，在SKOV3细胞中为23.6±1.9μM。然而，使用的Geraniin达到最大浓度(80μM)对正常人卵巢表面上皮细胞的存活率没有显著影响。与对照OVCAR3细胞(3.9±1.1％)相比，用10和40μM的Geraniin处理48小时导致细胞凋亡显著增加(分别为16.8±1.2％和22.6±1.4％)。在SKOV3细胞中观察到类似的结果[2]。 |
| In Vivo | 与对照组相比，在应用冈田酸之前用Geraniin治疗延迟了肿瘤的发展，将携带肿瘤的小鼠的百分比从80.0％降低到40.0％，并且在第20周将每只小鼠的平均肿瘤数从3.8降低到1.1。研究还表明，大鼠口服葛根素(50 mg/kg/d或100 mg/kg/d)可抑制血清总胆固醇，脂质过氧化物，游离脂肪酸，甘油三酯，谷氨酸草酰转氨酶和谷氨酸丙酮酸转氨酶的升高。用过氧化油处理[1]。 |
| Cell Experiment | 使用人卵巢癌细胞系OVCAR3和SKOV3。将细胞暴露于不同浓度(5，10，20，40和80μM)的Geraniin 48小时，并检查活力，细胞凋亡和基因表达。根据以前的研究[2]选择浓度范围。 |
| Data Literature Source | [1]. Okabe S，et al. New TNF-alpha releasing inhibitors，geraniin and corilagin，in leaves of Acer nikoense，Megusurino-ki. Biol Pharm Bull. 2001 Oct;24(10):1145-8. [2]. Wang X，et al. Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression. J Biochem Mol Toxicol. 2017 Sep;31(9). |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO 20mg |
Geraniin 是肿瘤坏死因子α (TNF-α) 的释放抑制剂。具有抗肿瘤、抗炎、抗高血糖活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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