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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Gallic AcidCAS：149-91-7
Molecular Formula：C7H6O5
Molecular Weight：170.12
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 149-91-7 |
| Name | Gallic Acid |
| Molecular Formula | C7H6O5 |
| Molecular Weight | 170.12 |
| Solubility | Soluble in DMSO ≥1mg/mL;Soluble in Ethanol ≥5mg/mL;Soluble in Water ≥12mg/mL(Need ultrasonic or Water bath) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-749-9 |
| MDL | MFCD00002510 |
| SMILES | O=C(O)C1=CC(O)=C(O)C(O)=C1 |
| InChIKey | LNTHITQWFMADLM-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12) |
| PubChem CID | 370 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Gallic acid is an inhibitor of COX-2. |
| Biological Activity | Gallic acid 是 COX-2 的抑制剂。[1-3] |
| In Vitro | 没食子酸是一种能够抑制COX-2的抗氧化剂[1]。用没食子酸处理18小时后，活的中性粒细胞的数量从40.3％急剧下降到27.7％，与未处理的中性粒细胞的26.4％高度相当。没食子酸不能减弱异丙肾上腺素诱导的肌细胞溶解[3]。 |
| In Vivo | 食品摄入量(2.6±0.08克/天，p = 0.69)和没食子酸组的体重(2.5±0.69 g，p = 0.76)与对照组没有显着差异(食物摄入量; 2.41± 0.14克/天，体重; 2.83±0.84克/天)。治疗2周后，没食子酸组的血糖耐受性显着提高。在2周的治疗期后，没食子酸组的血糖耐受性在90和120分钟时也显着优于对照组(p <0.05)。相对于对照组(1.08±0.20mM)，没食子酸组中的血清甘油三酯浓度(0.67±0.03mM，p <0.05)显着降低。对照组(3.19±0.27 mM)和没食子酸组(3.01±0.18 mM)的总胆固醇浓度相似[2]。 |
| Cell Experiment | 用RPMI1640/10％FBS中的8μg/ mL没食子酸处理嗜中性粒细胞3小时，6小时，9小时和18小时。在没食子酸处理结束时，根据制造商的说明用Annexin V-FITC和PI染色细胞。简而言之，用冰冷的PBS洗涤细胞两次，并以1×10 6个细胞/ mL的浓度重悬于1×结合缓冲液中。将细胞悬浮液(100μL中的1×10 5个细胞)与5μL膜联蛋白V-FITC和10μLPI在5mL培养管中在室温下孵育20分钟。在流式细胞仪系统上立即分析染色的细胞[3]。 |
| Animal Experiment | 在该研究中使用5周龄雄性C57BL/6小鼠。将动物保持在22℃的温控室中，12小时光暗光照。将小鼠分成对照载体组和没食子酸组。持续2周，每天用载体(10％酒精，10％吐温80和80％盐水)单独或用10mg/kg没食子酸给小鼠施用腹膜内治疗。在该处理之后，再次进行GTT，并取血样用于随后的生化分析。在实验期间，每天测量食物摄入量和体重[2]。 |
| Data Literature Source | [1]. Amaravani M，et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58. [2]. Bak EJ，et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14. [3]. Cheng Y，et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase Oxid Med Cell Longev. 2015;2015:434052. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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