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My CartCAS：524-30-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 524-30-1 |
| Name | Fraxin |
| Molecular Formula | C16H18O10 |
| Molecular Weight | 370.31 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-355-5 |
| MDL | MFCD00010093 |
| SMILES | OC1=C(OC)C=C(C=C2)C(OC2=O)=C1O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | Fraxin is a glycoside of ash lactone and has antioxidant, anti-inflammatory and anti-metastatic activities. |
| Biological Activity | Fraxin是白蜡树内酯的一种糖苷[1]，并具有抗氧化、抗炎和抗转移活性。Fraxin 通过抑制环腺苷酸磷酸二酯酶表现出抗氧化活性[2]。 |
| In Vitro | Fraxin(100μM)对Hep G2细胞无细胞毒性。非细胞毒性浓度的Fraxin以剂量依赖的方式显著降低t-BHP诱导的ROS产生[1]。 Fraxin(0.5 mM)在高浓度下具有清除自由基的作用，对H2O2介导的氧化应激具有细胞保护作用[2]。 |
| In Vivo | Fraxin(50 mg/kg，po)显著阻断CCl4诱导的ALT和AST升高。与CCl4处理组的GSSG水平相比，Fraxin(10和50 mg/kg，po)显著降低GSSG水平(分别为1.7±0.3和1.5±0.2 nM/g肝脏)[1]。 |
| Data Literature Source | [1]. Fraxin (50 mg/kg，p.o.) significantly blocks the CCl4-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg，p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver，respectively) compared with the GSSG levels of the CCl4-treated group[1]. [2]. Whang WK，et al. Natural compounds，fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 2005 Oct 31;37(5):436-46. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Fraxin 是白蜡树内酯的一种糖苷，并具有抗氧化、抗炎和抗转移活性。通过抑制环腺苷酸磷酸二酯酶表现出抗氧化活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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