{{cart_num}}
My CartCAS：528-48-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 528-48-3 |
| Name | Fisetin |
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.24 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-434-4 |
| MDL | MFCD00006829 |
| SMILES | O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC=C13 |
| Target Point | Sirtuin |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | Fisetin is a flavonol, which is an effective Sirtuin activating compound and can regulate Sirtuin. It has antioxidant, anticancer, neuroprotective and other physiological activities. |
| Biological Activity | Fisetin是一种在许多水果和蔬菜中发现的天然黄酮醇，具有多种益处，如抗氧化，抗癌，神经保护作用。[1-2] |
| In Vitro | Fisetin抑制脂质积累并抑制3T3-L1细胞中PPARγ的表达。Fisetin抑制前脂肪细胞分化的早期阶段，并诱导Sirt1的表达。Fisetin促进Sirt1介导的PPARγ和FoxO1的去乙酰化，并增强Sirt1与PPARγ启动子的结合，导致PPARγ转录活性的抑制，从而抑制脂肪形成[1]。Fisetin与微管蛋白结合并稳定微管，其结合特性远远优于紫杉醇。人前列腺癌细胞的Fisetin治疗导致微管相关蛋白(MAP)-2和-4的强烈上调。Fisetin显著抑制PCa细胞增殖，迁移和侵袭。 Nudc是一种与微管运动动力蛋白/ dynactin复合物相关的调节微管动力学的蛋白质，用Fisetin处理抑制[2]。 |
| Data Literature Source | [1]. Kim SC，et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44. [2]. Mukhtar E，et al. Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells. Cancer Lett. 2015 Oct 28;367(2):173-83 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
