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My CartCAS：29741-09-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 29741-09-1 |
| Name | Apigenin-7-O-glucronide |
| Molecular Formula | C21H18O11 |
| Molecular Weight | 446.36 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23699539 |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O |
| InChIKey | JBFOLLJCGUCDQP-ZFORQUDYSA-N |
| InChI | InChI=1S/C21H18O11/c22-9-3-1-8(2-4-9)13-7-12(24)15-11(23)5-10(6-14(15)31-13)30-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21-23,25-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1 |
| PubChem CID | 5319484 |
| Target Point | MMP |
| Passage | Metabolic Enzyme&Protease |
| Background | It inhibits the activity of matrix metalloproteinases (MMPs). |
| Biological Activity | Apigenin-7-glucuronide 能够抑制基质金属蛋白酶 (MMP) 的活性，其对 MMP-3，MMP-8，MMP-9，MMP-13 的IC50 值分别为 12.87，22.39，17.52，0.27 μM。[1-2] |
| IC50 | MMP-3:12.87μM;mMP-8:22.39μM;mMP-9:17.52μM;mMP13:0.27μM [1-2] |
| In Vitro | 芹菜素-7-Oglucuronide可抑制基质金属蛋白酶(MMP)活性，MMP-3，MMP-8，MMP-9，MMP-13的IC50分别为12.87，22.39，17.52，0.27μM[1]。灯盏花素A还以剂量依赖性方式抑制ACHN和786-O细胞的迁移能力。还显示，与对照组相比，用灯盏花素A(30，60和90μM)处理24小时后，ACHN和786-O细胞的凋亡率显著增强，呈剂量依赖性[2]。 |
| Data Literature Source | [1]. Crascì L，et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911. [2]. Deng W，et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother. 2018 Nov;107:1505-1513. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
能够抑制基质金属蛋白酶 (MMP) 的活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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