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My CartCAS：29883-15-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 29883-15-6 |
| Name | Amygdalin |
| Molecular Formula | C20H27NO11 |
| Molecular Weight | 457.43 |
| Solubility | Soluble in Water ≥10mg/mL;Soluble in DMSO ≥100mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 249-925-3 |
| MDL | MFCD00006598 |
| SMILES | O[C@H]1[C@H](O[C@@H](C#N)C2=CC=CC=C2)O[C@H](CO[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H](O)[C@@H]1O |
| InChIKey | XUCIJNAGGSZNQT-JHSLDZJXSA-N |
| InChI | InChI=1S/C20H27NO11/c21-6-10(9-4-2-1-3-5-9)30-20-18(28)16(26)14(24)12(32-20)8-29-19-17(27)15(25)13(23)11(7-22)31-19/h1-5,10-20,22-28H,7-8H2/t10-,11+,12+,13+,14+,15-,16-,17+,18+,19+,20+/m0/s1 |
| PubChem CID | 656516 |
| Target Point | Others |
| Passage | Others |
| Background | It is a glycoside mainly found in the nuts and leaves of bitter apricots, bitter almonds, peaches, nectarines, loquats, plums, apples, and black cherries. |
| In Vitro | Amygdalin具有抗肿瘤活性。关于Amygdalin的抗肿瘤机制已取得一些进展[1]。Amygdalin特别下调属于细胞周期类别的基因：外切核酸酶1，ATP结合盒，亚家族F，成员2，MRE11减数分裂重组11同源物A，拓扑异构酶(DNA)I和FK506结合蛋白12-雷帕霉素相关蛋白1 RT-PCR分析显示，在SNU-C4人结肠癌细胞中，Amygdalin处理也会降低这些基因的mRNA水平[2]。 |
| In Vivo | Amygdalin可有效缓解炎症疼痛，并可用作具有抗伤害性和抗炎活性的镇痛药。肌肉注射Amygdalin在早期(福尔马林注射后最初10分钟)和晚期(最初福尔马林注射后10-30分钟)显著降低福尔马林诱导的强直性疼痛。在晚期，Amygdalin以剂量依赖性方式减少福尔马林诱导的疼痛，剂量范围小于1 mg/kg [3]。 |
| Cell Experiment | 通过MTT测定确定细胞活力。将细胞以1×10 5个细胞/孔的浓度一式三份接种在96孔板上。用浓度为0.25，0.5，2.5和5mg/mL的Amygdalin处理SNU-C4细胞24小时。将MTT加入各组后，将细胞培养4小时。然后，将它们进一步温育1小时，包括溶解MTT的溶液[2]。 |
| Animal Experiment | 大鼠：将Amygdalin粉末溶解在盐水中并用适当的培养基稀释。将重230-250g的雄性Sprague-Dawley大鼠用于该实验。注射50mL的5％福尔马林以在大鼠中产生fomalin诱导的疼痛。在福尔马林注射诱导疼痛前30分钟，给予大鼠肌肉注射Amygdalin溶液(0.1，0.5，1.0，10mg/kg)或盐水作为媒介物对照[3]。 |
| Data Literature Source | [1]. Song Z，et al. Advanced research on anti-tumor effects of amygdalin. J Cancer Res Ther. 2014 Aug;10 Suppl 1:3-7. [2]. Park HJ，et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol. 2005 Sep 7;11(33):5156-61. [3]. Hwang HJ，et al. Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biol Pharm Bull. 2008 Aug;31(8):1559-64. |
| Unit | Piece |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
是一种糖苷，主要存在于苦杏、苦扁桃、桃、油桃(nectarines)、枇杷、李子、苹果、黑樱桃等果仁和叶子中。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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