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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Bovine Serum AlbuminCAS：9048-46-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 9048-46-8 |
| Name | Bovine Serum Albumin |
| Molecular Weight | ≈66kDa |
| Solubility | Soluble in Water/D-PBS/0.85%NaCl ≥100mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 232-936-2 |
| MDL | MFCD00131855 |
| Target Point | Others |
| Passage | Others |
| Background | It is a globulin in bovine serum and can be used in a variety of biochemical experiments. It is generally used as a stabilizer in the storage solution and reaction solution of restriction enzymes or modified enzymes, and can also prevent enzymes from being adsorbed to the tube wall and lost. Contributes to the stability and activity of Taq enzyme in the PCR system, and can improve the efficiency of PCR) |
| Biological Activity | Bovine Serum Albumin (BSA) 是由三个同源全 α 结构域组成的 583 个氨基酸的蛋白质。BSA 是一种球状蛋白，可用于多种生物化学实验。[1] |
| In Vitro | 牛血清白蛋白(BSA)是由三个同源的全α结构域组成的583残基蛋白，以心形结构组织。牛血清白蛋白构成ca.所有血浆蛋白的60％并且结合并运输大量生理和非生理配体。牛血清白蛋白含有17个二硫键和一个未配对的半胱氨酸(Cys34)，其促进二聚化并且还影响高级缔合，因为如果Cys34与另一种化合物共价结合，则聚集速率减慢。用于原纤维细胞毒性的MTT测定显示牛血清白蛋白有利于细胞生长，而不管其聚集状态。通过膜透化测定证实缺乏细胞毒性。在随后的40小时中，观察到处理细胞的存活率增加300-400％，表明与牛血清白蛋白一起孵育的细胞比未处理的细胞具有更高的存活率[1]。 |
| Cell Experiment | 在96孔微量培养板中制备样品，并且所有不含样品的孔用200μLPBS填充以使蒸发最小化。向每个孔加载100μLSH-SY5Y生长培养基，含或不含10.000 SH-SY5Y神经母细胞瘤细胞。通过添加25μL缓冲液开始测定，其中有或没有5mg/mL超声处理的牛血清白蛋白，其预先在70℃温育0，2或96小时(给出最终BSA浓度为1mg/mL)。将所有样品组合装入三联体中，并且对于六种牛血清白蛋白组合中的每一种，加载相应的三联体而不含细胞，用作空白。一个三联体也没有细胞和BSA，只有一个没有牛血清白蛋白[1]。 |
| Data Literature Source | [1]. Holm NK，et al. Aggregation and fibrillation of bovine serum albumin. Biochim Biophys Acta. 2007 Sep;1774(9):1128-38 |
| Unit | Piece |
| Specification | 200mg 1g 5g |
是牛血清中的一种球蛋白，可用于多种生物化学实验。一般做为稳定剂被用于限制酶或者修饰酶的保存溶液和反应液中，还能防止酶吸附到管壁而损失。在PCR体系中有助于Taq酶的稳定性及活性，可以提高PCR的效率
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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